{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:59:26Z","timestamp":1787169566165,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Dry eye disease (DED) is a multifactorial disease, more prevalent among visual display terminal users. Reduced blink rate is a risk factor to dry eye disorder, innovative means to remind to blink while using computers can be helpful.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Single-blinded Randomized Control Trial enrolled computer users with dry eye. Allocation concealment was done using opaque envelope and principal investigator was blinded. After baseline examination, eligible participants were randomized to intervention group (appearance of bars is 8 times\/min) and control group (appearance of bars is 1 time\/min). Participants from both groups used the software for 15 days, came for first follow up, and did not use the software for next 15 days until second follow-up examination. During each visit, detailed eye examination was done including blink rate, tear film break up time, and Ocular Surface Disease Index score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Forty-six participants (women\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 31; men\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 15) with a mean age of 28.02 (\u00b16.295) years completed the study. Four participants were excluded from analysis because of early dropout. In the intervention group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 23) and control group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 23), participants were allocated. At the end of first phase, there was statistically significant difference in OSDI score (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.021). Statistically significant difference was noticed in OSDI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.014) and blink rate (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.049) as baseline, and final visit data were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\u201cBlink\u2013Blink\u201d software with 8 reminders\/min improved DED-related symptoms by increasing the blink rate. The carry-over effect after cessation of Blink-Blink software in improving blink rate was maintained even after 1 month.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration<\/jats:bold>\n                      : Clinical Trials Registry-India (CTRI): CTRI\/2018\/08\/015176\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_3405_20","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T11:42:39Z","timestamp":1633434159000},"page":"2643-2648","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of blink software in improving the blink rate and dry eye symptoms in visual display terminal users \u2013 A single-blinded randomized control trial"],"prefix":"10.4103","volume":"69","author":[{"given":"D L","family":"Ashwini","sequence":"first","affiliation":[{"name":"Department of Optometry, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India"},{"name":"Sankara College of Optometry, Sankara Eye Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh S","family":"Ve","sequence":"additional","affiliation":[{"name":"Department of Optometry, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Nosch","sequence":"additional","affiliation":[{"name":"FHNW University of Applied Sciences and Northwestern Switzerland, School of Engineering, Riggenbachstrasse 16 CH-4600 Olten, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natoya","family":"Wilmot","sequence":"additional","affiliation":[{"name":"Department of Optometry, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Udupi, 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