{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:39:07Z","timestamp":1791088747300,"version":"4.1.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The present study was done to assess the use of optical coherence tomography angiography (OCTA) in detecting earlier stages of diabetic retinopathy and for the early management and effective blood glucose control in preclinical diabetic patients for preventing retinal nerve fiber layer (RNFL) thinning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A tertiary care center\u2013based prospective observational study was conducted from the year 2021 to 2022 in the Department of Ophthalmology. The study included 50 cases and 50 controls. The parameters analyzed by using OCTA (Topcon 3D OCT-1 Maestro2) were RNFL thickness and peripapillary vessel density.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We found that the RNFL thickness in the temporal and superior disc in patients with preclinical diabetic retinopathy was significantly (0.041 and 0.044, respectively) decreased. The duration of diabetes and glycated hemoglobin (HbA1c) were the risk factors for peripapillary vessel density reduction in patients with preclinical diabetic retinopathy (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>RNFL thinning is an early sign of retinal neurodegeneration and is associated with peripapillary vessel density reduction. Early management and effective blood glucose control in diabetes patients may be beneficial for preventing RNFL thinning in superior and temporal disc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_340_23","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T01:01:22Z","timestamp":1703206882000},"page":"S11-S15","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Quantitative measurement of retinal nerve fiber layer thickness and its correlation with optical coherence tomography angiography vascular biomarker changes in preclinical diabetic retinopathy"],"prefix":"10.4103","volume":"72","author":[{"given":"Shweta","family":"Verma","sequence":"first","affiliation":[{"name":"Regional Institute of Ophthalmology, M.L.N. Medical College, Prayagaraj, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Regional Institute of Ophthalmology, M.L.N. Medical College, Prayagaraj, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagriti","family":"Rana","sequence":"additional","affiliation":[{"name":"Regional Institute of Ophthalmology, M.L.N. Medical College, Prayagaraj, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Regional Institute of Ophthalmology, M.L.N. Medical College, Prayagaraj, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamaljeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Regional Institute of Ophthalmology, M.L.N. Medical College, Prayagaraj, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratnapriya","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Regional Institute of Ophthalmology, M.L.N. 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patients with diabetes mellitus: An optical coherencetomography angiography study\u201d","volume":"9","author":"Yong-Il","year":"2019","journal-title":"Sci Rep"},{"key":"R11-20260508","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/jcor.jcor_78_19","article-title":"Study of peripapillary retinal nerve fiber layer thickness in patients of type 2 diabetes mellitus and its correlation with glycemic control","volume":"9","author":"Menezes","year":"2021","journal-title":"J Clin Ophthalmol Res"},{"key":"R12-20260508","first-page":"7776","article-title":"Retinal nerve and vascular changes in prediabetes","volume":"9","author":"Peng","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"R13-20260508","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1167\/iovs.18-24891","article-title":"Peripapillary microvascular and neural changes in diabetes mellitus: An OCT-angiography study","volume":"59","author":"Vujosevic","year":"2018","journal-title":"Invest Ophthalmol 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