{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:19:38Z","timestamp":1789759178290,"version":"4.0.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate long-term intraocular pressures that provide stabilization\/reversal of glaucomatous neuropathy after surgery in primary congenital glaucoma (PCG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Prospective evaluation of consecutive PCG patients who underwent trabeculectomy-trabeculotomy and followed up for \u22652 years. Records of regularly performed examination under anesthesia were maintained to ascertain intraocular pressure, (IOP), fundus, refraction and corneal diameter. Outcomes \u2013 Primary: cup: disc ratio and intraocular pressure, Secondary: corneal changes and refractive error<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 174 eyes of 108 children with PCG had a preoperative IOP of 22.44 \u00b1 9.5 mm Hg. Postoperative review IOP was 11.8 \u00b1 4.5 mm Hg, cup-disc-ratio was 0.52 \u00b1 0.23 and corneal diameter was 12.75 \u00b1 0.9 mm. Primary outcomes: Linear regression analysis showed a significant positive correlation of review IOP with cup disc ratio,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004. 67.9%, of eyes at a review IOP range of 6-12 mm Hg showed reversal, 14.1%, were stable, at 6-15 mm Hg, while 3.84% showed an increase in cup: disc ratio 16-22 mm Hg. Patients operated before 6 months of age had a significantly smaller final cup-disc ratio,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0013. Patients with a final cup: disc ratio of &gt;0.9 were significantly older at surgery,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001. Secondary outcomes: There was a positive correlation of final myopia with review IOP on linear regression analysis,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.012. The final spherical error in eyes having cup disc ratio of \u2264 0.5 was \u20130.96 \u00b1 4.5 diopters, as against -3.45 \u00b1 7.7 diopters in eyes having cup-disc ratio of 0.6-0.8 and -3.8 \u00b1 6.9 diopters in eyes with cup disc ratio of \u22650.9,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.015. There was no significant change in corneal diameter.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients operated after 6 months of age had a larger final cup: disc ratio, while postoperative review intraocular pressures over 2 years of at least \u226415 mm Hg in primary congenital glaucoma eyes, commonly lead to reversal\/stability of the neuropathy, and a lower incidence and degree of myopia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_3473_20","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T10:22:48Z","timestamp":1627899768000},"page":"2082-2087","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Evaluating target intraocular pressures in primary congenital 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