{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:21:27Z","timestamp":1787761287502,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Infectious retinitis postfebrile illness is known to be caused by chikungunya, dengue, West Nile virus, Bartonella, Lyme's disease, Rift Valley fever, rickettsia, Herpes viruses etc. Rickettsia is Gram-negative bacteria transmitted by arthropods vectors. Ocular involvement is common including conjunctivitis, keratitis, anterior uveitis, panuveitis, retinitis, retinal vascular changes, and optic nerve involvement. Retinitis lesions in rickettsia can occur because of an immunological response to the bacteria or because of direct invasion and proliferation of bacteria in the inner retina. We report such a case of bilateral rickettsial retinitis proven by serology which worsened on systemic steroids and responded dramatically to therapy with oral doxycycline and steroid taper. We thus believe that direct bacterial invasion plays a major role in the pathogenesis of rickettsial retinitis.<\/jats:p>","DOI":"10.4103\/ijo.ijo_369_17","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T08:58:30Z","timestamp":1508230710000},"page":"1038-1041","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Rickettsial retinitis: Direct bacterial infection or an immune-mediated response?"],"prefix":"10.4103","volume":"65","author":[{"given":"Rohan","family":"Chawla","sequence":"first","affiliation":[{"name":"Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gadkar Amit","family":"Pundlik","sequence":"additional","affiliation":[{"name":"Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandan","family":"Thakur","sequence":"additional","affiliation":[{"name":"Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251013","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s13312-010-0024-3","article-title":"Rickettsial infections: Indian perspective","volume":"47","author":"Rathi","year":"2010","journal-title":"Indian Pediatr"},{"key":"R2-20251013","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ophtha.2003.04.012","article-title":"Posterior segment manifestations of Rickettsia conorii infection","volume":"111","author":"Khairallah","year":"2004","journal-title":"Ophthalmology"},{"key":"R3-20251013","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4103\/0974-9233.58426","article-title":"Emergent infectious uveitis","volume":"16","author":"Khairallah","year":"2009","journal-title":"Middle East Afr J Ophthalmol"},{"key":"R4-20251013","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s10792-009-9319-6","article-title":"Novel infectious agents causing uveitis","volume":"30","author":"Khairallah","year":"2010","journal-title":"Int Ophthalmol"},{"key":"R5-20251013","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4103\/0019-557X.119817","article-title":"Rickettsiosis: A cause of acute febrile illness and value of Weil-Felix test","volume":"57","author":"Ajantha","year":"2013","journal-title":"Indian J Public Health"},{"key":"R6-20251013","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1097\/IAE.0000000000000218","article-title":"Spectral domain optical coherence tomography in the evaluation and management of infectious retinitis","volume":"34","author":"Kurup","year":"2014","journal-title":"Retina"},{"key":"R7-20251013","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12348-015-0066-8","article-title":"Rickettsial retinitis-an Indian perspective","volume":"5","author":"Kawali","year":"2015","journal-title":"J Ophthalmic Inflamm Infect"},{"key":"R8-20251013","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1128\/br.24.1.96-105.1960","article-title":"Relation of cell metabolism to infection with rickettsial and bacterial agents","volume":"24","author":"Cohn","year":"1960","journal-title":"Bacteriol Rev"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223307-201765100-00032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:31:00Z","timestamp":1787758260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223307-201765100-00032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":8,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_369_17","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"2017-05-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}