{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:06:38Z","timestamp":1787169998660,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To study the prevalence of glaucoma among adults with migraine and the effect of migraine on peripapillary retinal nerve fiber layer (pRNFL) and central macular thickness (CMT) using optical coherence tomography (OCT) compared to those without migraine headache, i.e. in tension-type headache (TTH) and normal group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>One hundred and eleven patients (222 eyes) were recruited in three groups. migraine, TTH, and normal subjects visiting hospital outpatient services. After noting demographic details and pertinent history, ophthalmological evaluation including optic disc for glaucomatous changes along with computerized visual field testing and OCT for pRNFL thickness and CMT was performed in all eyes. Continuous variables were compared using ANOVA or Kruskal\u2013Wallis test, while categorical variables including the association of glaucoma with migraine were analyzed using Chi-square or Fisher\u2019s exact test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Prevalence of glaucoma in migraine group (12.2%) was more than in comparison groups (6.8% in TTH, 4.1% in normal) which was however not significant (Fisher\u2019s exact\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.207). Average pRNFL thickness (103.59 \u00b1 12.82 \u03bcm) and thickness in nasal (90.49 \u00b1 19.19 \u03bcm) and temporal quadrants (70.58 \u00b1 16.13 \u03bcm) and CMT (213.78 \u00b1 19.81 \u03bcm) were significantly reduced (ANOVA\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) in migraine patients when compared to the other groups and this was independent of the presence of glaucoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Prevalence of glaucoma is not significantly higher in migraine patients. However, migraine causes thinning of retinal layers on OCT that is statistically significant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_375_21","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T06:54:59Z","timestamp":1638255299000},"page":"3546-3551","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Glaucoma and optical coherence tomography changes in migraine: A comparative cross-sectional study"],"prefix":"10.4103","volume":"69","author":[{"given":"Gayathri","family":"Panicker","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, JIPMER, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subashini","family":"Kaliaperumal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, JIPMER, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Narayan","sequence":"additional","affiliation":[{"name":"Department of Neurology, JIPMER, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malavika","family":"Mani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, JIPMER, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1468-2982.2007.01288.x","article-title":"The global burden of headache:A documentation of headache prevalence and disability worldwide","volume":"27","author":"Stovner","year":"2007","journal-title":"Cephalalgia"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.optom.2016.02.003","article-title":"Glaucoma history and risk factors","volume":"10","author":"McMonnies","year":"2017","journal-title":"J Optom"},{"key":"B3-20240828","first-page":"140","article-title":"The impact of fibromyalgia on disability, anxiety, depression, sleep disturbance and quality of life in patients with migraine","volume":"55","author":"Beyazal","year":"2018","journal-title":"Noro Psikiyatr Ars"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/00004647-199902000-00001","article-title":"The trigeminovascular system in humans:Pathophysiologic implications for primary headache syndromes of the neural influences on the cerebral circulation","volume":"19","author":"May","year":"1999","journal-title":"J Cereb Blood Flow Metab"},{"key":"B5-20240828","first-page":"1105","article-title":"Migraine and low-tension glaucoma. 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