{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:27:16Z","timestamp":1787758036012,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe the clinical profile and treatment outcomes of infants with retinopathy of prematurity (ROP) presenting with isolated exudative retinal detachment (ERD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective interventional case series. Preterm infants diagnosed with ROP with ERD at presentation were included. All demographic details, clinical findings, and treatment given were documented. The anatomical outcome was categorized as good, fair, and poor. Refractive outcome was classified into mild, moderate, and severe according to spherical equivalent at the last visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifteen eyes (8 patients) were included. Mean gestational age was 31.3 weeks, and birth weight was 1462.6 g. All eyes presented with aggressive ROP. Patches of retinal edema in avascular retina were seen in all eyes. A total of 86.6% of eyes had vascular sclerosis while 86.6% of eyes had subretinal exudates. The anatomical outcome was good in all eyes. In addition, 40% of eyes had a mild refractive error.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Exudative retinal detachment in ROP is rare. The use of unregulated oxygen can be a contributory factor. Vascular sclerosis is consistent with hyperoxia-induced retinopathy models. Retinal edema and subretinal exudates indicate disrupted inner and outer blood-retinal barrier. Treatment outcomes are good when diagnosed and treated in time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_407_22","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T06:28:32Z","timestamp":1657607312000},"page":"2486-2489","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Exudative retinal detachment as an initial presentation of retinopathy of prematurity: Clinical profile and outcomes of a rare presentation"],"prefix":"10.4103","volume":"70","author":[{"given":"Komal","family":"Agarwal","sequence":"first","affiliation":[{"name":"Smt Kanuri Santhamma Center for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Jayanna","sequence":"additional","affiliation":[{"name":"Smt Kanuri Santhamma Center for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad, Telangana, India"},{"name":"Department of Ophthalmology, Jigme Dorji Wangchuk National Referral Hospital, Thimpu, Bhutan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapas Ranjan","family":"Padhi","sequence":"additional","affiliation":[{"name":"Retina and Vitreous Service, Mithu Tulsi Chanrai Campus, L V Prasad Eye Institute, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhadra","family":"Jalali","sequence":"additional","affiliation":[{"name":"Smt Kanuri Santhamma Center for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jcjo.2013.12.014","article-title":"Intravitreal bevacizumab for exudative retinal detachment post laser therapy for retinopathy of prematurity","volume":"49","author":"Ehmann","year":"2014","journal-title":"Can J Ophthalmol"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/IAE.0b013e3182993d5f","article-title":"Exudative retinal detachment following photocoagulation in older premature infants for retinopathy of prematurity:Description and management","volume":"34","author":"Moshfeghi","year":"2014","journal-title":"Retina"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1038\/s41433-020-01223-0","article-title":"Bleb-like posterior combined retinal detachment in severe retinopathy of prematurity:Clinical characteristics, management challenges and outcome [published online ahead of print, 2020 Oct 17]","volume":"35","author":"Patel","year":"2021","journal-title":"Eye (Lond)"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1016\/j.jcjo.2017.07.007","article-title":"Exudative retinal detachment, a primary presentation in retinopathy of prematurity","volume":"53","author":"Sen","year":"2018","journal-title":"Can J Ophthalmol"},{"key":"B6-20240828","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jaapos.2020.07.006","article-title":"Exudative retinal detachment as an initial presentation in retinopathy of prematurity","volume":"24","author":"Jayanna","year":"2020","journal-title":"J AAPOS"},{"key":"B7-20240828","article-title":"A rare case of aggressive posterior retinopathy of prematurity presenting with exudative retinal detachment [published online ahead of print, 2020 Nov 2]","author":"Mittal","year":"2020","journal-title":"J AAPOS"},{"key":"B8-20240828","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4103\/ijo.IJO_2440_20","article-title":"Exudative retinal detachment in treatment na\u00efve aggressive posterior retinopathy of prematurity:A case report","volume":"1","author":"Mohideen","year":"2021","journal-title":"Indian J Ophthalmol Case Rep"},{"key":"B10-20240828","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.survophthal.2017.05.001","article-title":"Exudative retinal detachment","volume":"62","author":"Amer","year":"2017","journal-title":"Surv Ophthalmol"},{"key":"B11-20240828","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ophtha.2014.07.050","article-title":"Pathophysiology and mechanisms of severe retinopathy of prematurity","volume":"122","author":"Hartnett","year":"2015","journal-title":"Ophthalmology"},{"key":"B12-20240828","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1001\/archopht.1984.01040030052033","article-title":"The eye in accelerated hypertension II. Localized serous detachments of the retina in patients","volume":"102","author":"de Venecia","year":"1984","journal-title":"Arch Ophthalmol"},{"key":"B13-20240828","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4103\/0301-4738.128639","article-title":"Aggressive posterior retinopathy of prematurity in infants\u22651500 g birth weight","volume":"62","author":"Sanghi","year":"2014","journal-title":"Indian J Ophthalmol"},{"key":"B14-20240828","doi-asserted-by":"crossref","first-page":"F371","DOI":"10.1136\/fetalneonatal-2011-301121","article-title":"Aggressive posterior retinopathy of prematurity in large preterm babies in South India","volume":"97","author":"Shah","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"B15-20240828","first-page":"323","article-title":"Familial exudative vitreoretinopathy (FEVR). Clinical profile and management","volume":"51","author":"Shukla","year":"2003","journal-title":"Indian J Ophthalmol"},{"key":"B16-20240828","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3928\/23258160-20151214-02","article-title":"Retinopathy of prematurity versus familial exudative vitreoretinopathy:Report on clinical and angiographic findings","volume":"47","author":"John","year":"2016","journal-title":"Ophthalmic Surg Lasers Imaging Retina"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_407_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:02:59Z","timestamp":1787756579000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_407_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,30]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_407_22","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,30]]},"assertion":[{"value":"2022-02-10","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-31","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}