{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:22:04Z","timestamp":1787757724223,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>There are no effective treatments currently available for optic nerve transection injuries. Stem cell therapy represents a feasible future treatment option. This study investigated the therapeutic potential of human umbilical cord\u2013derived mesenchymal stem cell (hUC-MSC) transplantation in rats with optic nerve injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Sprague\u2013Dawley (SD) rats were divided into three groups: a no-treatment control group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 6), balanced salt solution (BSS) treatment group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 6), and hUC-MSCs treatment group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 6). Visual functions were assessed by flash visual evoked potential (fVEP) at baseline, Week 3, and Week 6 after optic nerve crush injury. Right eyes were enucleated after 6 weeks for histology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The fVEP showed shortened latency delay and increased amplitude in the hUC-MSCs treated group compared with control and BSS groups. Higher cellular density was detected in the hUC-MSC treated group compared with the BSS and control groups. Co-localized expression of STEM 121 and anti-S100B antibody was observed in areas of higher nuclear density, both in the central and peripheral regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Peribulbar transplantation of hUC-MSCs demonstrated cellular integration that can potentially preserve the optic nerve function with a significant shorter latency delay in fVEP and higher nuclear density on histology, and immunohistochemical studies observed cell migration particularly to the peripheral regions of the optic nerve.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_473_21","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T06:00:43Z","timestamp":1640584843000},"page":"201-209","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic potential of human umbilical cord\u2013derived mesenchymal stem cells transplantation in rats with optic nerve injury"],"prefix":"10.4103","volume":"70","author":[{"given":"Sook Y.","family":"Looi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mae-Lynn C","family":"Bastion","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue N","family":"Leow","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi D","family":"Luu","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia"},{"name":"Ophthalmology Department of Surgery, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N MH","family":"Hairul","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raduan","family":"Ruhaslizan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hon S","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul H Wan","family":"Haslina","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min H","family":"Ng","sequence":"additional","affiliation":[{"name":"Tissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B Hj Idrus","family":"Ruszymah","sequence":"additional","affiliation":[{"name":"Tissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kong Y","family":"Then","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Melbourne, Australia"},{"name":"International Specialist Eye Centre, Midvalley, Kuala Lumpur, 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