{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:28:37Z","timestamp":1786649317471,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate changes in corneal backscattering after collagen cross-linking (CXL) for progressive keratoconus and compare its course with different techniques \u2013 standard epithelium-off CXL (SCXL), contact lens-assisted CXL (CACXL), and transepithelial CXL (TECXL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective comparative study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Ninety-four eyes (SCXL: 47, CACXL: 30, and TECXL: 17) were compared. Corneal haze was quantified using Scheimpflug tomography, pre- and post-CXL at 1, 3, 6, and 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The baseline mean density score of the central anterior stromal layer was 16.14 \u00b1 7.07, 15.85 \u00b1 7.89 and 15.89 \u00b1 7.21 in SCXL, CACXL, and TECXL groups, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      0.93). After SCXL, the score increased to 28.83 and 31.34 at 1 and 3 months, respectively (both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and dropped at 6 months (28.66,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and 12 months (23.72,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      0.003). Post-CACXL, the mean densitometry peaked at 3 months (20.35,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      0.14) and returned toward baseline at 6 months (18.82,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      0.15). After TECXL, it increased slightly at 1 month (18.47,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      0.17), decreased at 3 months (14.88,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      0.7), and plateaued over 1 year. No correlation with visual acuity was seen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Corneal haze increased significantly after SCXL, peaking at 3 months, declining over 6\u201312 months, and returning to baseline at 12 months. In contrast, post-TECXL and -CACXL, there was an insignificant increase in anterior corneal haze, which returned to baseline within 3\u20136 months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_485_24","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T03:01:44Z","timestamp":1726023704000},"page":"102-109","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Corneal densitometry changes post-CXL for keratoconus: Comparative evaluation of epithelium-off, contact lens-assisted, and transepithelial techniques"],"prefix":"10.4103","volume":"73","author":[{"given":"Barkha","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chintan","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Dhar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushdeep","family":"Abhyapal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"R1-20260424","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","article-title":"Riboflavin\/ultraviolet-a\u2013induced collagen crosslinking for the treatment of keratoconus","volume":"135","author":"Wollensak","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"R2-20260424","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/S0886-3350(03)00407-3","article-title":"Stress-strain measurements of human and porcine corneas after 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