{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:53:16Z","timestamp":1790553196081,"version":"4.1.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"\n Purpose:<\/jats:title>\n The objective of the study is to compare the frequency of Demodex on the eyelash follicle of patients with rosacea and referents without rosacea or ophthalmological disorders.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This is a comparative, open, observational, and cross-sectional study that included 41 patients diagnosed with rosacea and 41 referents without rosacea diagnosis or ophthalmic alterations. The individuals underwent a slit-lamp examination in which two eyelashes per eyelid were removed with fine forceps. The presence of Demodex was sought by direct visualization under a light microscope. The results were expressed as \u201cpositive\u201d when at least one mite on one lash was found and \u201cnegative\u201d when no mite was identified. Chi-square test was used to compare the presence of mites in both groups.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Eighty-two study individuals (45 females and 37 males) were included, of which 41 patients were diagnosed with rosacea and 41 were without rosacea or ophthalmic alterations. The average mean age was 37 years with a minimum of 19 and a maximum of 87 years. Of the 41 patients with rosacea, 31 had erythematotelangiectatic rosacea and 10 had papulopustular rosacea. There were no patients with phymatous or ocular rosacea. The presence of Demodex was found in 32 patients: 24 patients with rosacea diagnosis (16 of the erythematotelangiectatic subtype and 8 of papulopustular subtype) and 8 patients without rosacea or ophthalmic alterations (\n P<\/jats:italic>\n \u2264 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Rosacea was found to be a statistically significant risk factor for Demodex infestation in eyelashes, irrespective of age and sex, with a higher prevalence in papulopustular variety.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_514_17","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T09:45:03Z","timestamp":1514454303000},"page":"36-38","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":37,"title":["Demodex and rosacea: Is there a relationship?"],"prefix":"10.4103","volume":"66","author":[{"given":"Diana","family":"Gonzalez-Hinojosa","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hospital General Gea Gonzalez, Calzada de Tlalpan 4800, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Jaime-Villalonga","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital General Gea Gonzalez, Calzada de Tlalpan 4800, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Aguilar-Montes","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital General Gea Gonzalez, Calzada de Tlalpan 4800, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Lammoglia-Ordiales","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital General Gea Gonzalez, Calzada de Tlalpan 4800, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251013","first-page":"2","article-title":"Under the lash: Demodex mites in human diseases","volume":"31","author":"Lacey","year":"2009","journal-title":"Biochem (Lond)"},{"key":"R2-20251013","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jaad.2004.05.034","article-title":"Demodicosis and rosacea: Epidemiology and significance in daily dermatologic practice","volume":"52","author":"Forton","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"R3-20251013","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.3346\/jkms.2012.27.12.1574","article-title":"Ocular surface discomfort and demodex: Effect of tea tree oil eyelid scrub in demodex blepharitis","volume":"27","author":"Koo","year":"2012","journal-title":"J Korean Med Sci"},{"key":"R4-20251013","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1365-4362.1998.00218.x","article-title":"The significance of demodex folliculorum density in rosacea","volume":"37","author":"Erba\u01e7ci","year":"1998","journal-title":"Int J Dermatol"},{"key":"R5-20251013","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1167\/iovs.09-4850","article-title":"The relationship between demodex and ocular discomfort","volume":"51","author":"Lee","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R6-20251013","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1365-2133.1993.tb00261.x","article-title":"Density of demodex folliculorum in rosacea: A case-control study using standardized skin-surface biopsy","volume":"128","author":"Forton","year":"1993","journal-title":"Br J Dermatol"},{"key":"R7-20251013","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.clindermatol.2010.03.006","article-title":"Demodex mites: Facts and controversies","volume":"28","author":"Elston","year":"2010","journal-title":"Clin Dermatol"},{"key":"R8-20251013","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1365-2303.2009.00639.x","article-title":"Chronic blepharitis caused by demodex folliculorum mites","volume":"20","author":"Divani","year":"2009","journal-title":"Cytopathology"},{"key":"R9-20251013","doi-asserted-by":"crossref","first-page":"635","DOI":"10.4321\/S0365-66912005001100004","article-title":"Chronic blepharitis and demodex","volume":"80","author":"Rodr\u00edguez","year":"2005","journal-title":"Arch Soc Esp Oftalmol"},{"key":"R10-20251013","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.ophtha.2009.09.057","article-title":"Correlation between ocular demodex infestation and serum immunoreactivity to bacillus proteins in patients with facial rosacea","volume":"117","author":"Li","year":"2010","journal-title":"Ophthalmology"},{"key":"R11-20251013","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1167\/iovs.11-9295","article-title":"Demodex-associated bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line: Possible implications for corneal ulcer formation in ocular rosacea","volume":"53","author":"O\u2019Reilly","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223307-201866010-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:30:48Z","timestamp":1787758248000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223307-201866010-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_514_17","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-06-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}