{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:28:36Z","timestamp":1786649316003,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Prematurity has been known to trigger several cellular pathways, leading to the clinical occurrence of retinopathy of prematurity (ROP). This study compared the levels of a panel of serum cytokines in premature infants with and without ROP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a prospective observational study. Premature infants at 36\u201338 weeks\u2019 gestational age were recruited, their clinical data recorded, and serum samples collected and assayed for 18 cytokines. Based on follow-up examinations, patients were divided into two groups: No ROP and ROP. The ROP group was further divided into two subgroups: non-vision-threatening ROP (non-VTROP), and vision-threatening ROP (VTROP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>On univariate analysis, among the clinical parameters, gestation age, birth weight, duration of invasive ventilation, and duration of stay in neonatal intensive care unit (NICU) were found to be significant. The univariate analysis also showed an association between raised levels of VEGF-D and IL-8 in the VTROP group. Multiple logistic regression indicated that gestation age was a significant risk factor across all subgroups. Additionally, VEGF-D levels were found to be significantly associated with VTROP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Higher VEGF-D levels are associated with an increased risk of severe ROP that requires treatment and could potentially be used as a biomarker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_515_24","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T10:00:10Z","timestamp":1735034410000},"page":"S139-S143","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The association of cytokine levels and postnatal factors with retinopathy of prematurity"],"prefix":"10.4103","volume":"73","author":[{"given":"Syatirah Abu","family":"Yazib","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, UM Eye Research Centre, Faculty of Medicine, Universiti Malaya, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May May","family":"Choo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, UM Eye Research Centre, Faculty of Medicine, Universiti Malaya, Malaysia"},{"name":"Department of Ophthalmology, Central Clinical School, Faculty of Medicine, University of Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurliza","family":"Khaliddin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, UM Eye Research Centre, Faculty of Medicine, Universiti Malaya, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine PY","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, UM Eye Research Centre, Faculty of Medicine, Universiti Malaya, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao Mun","family":"Choo","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine, Universiti Malaya, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azanna Ahmad","family":"Kamar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine, Universiti Malaya, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal G","family":"Lingam","sequence":"additional","affiliation":[{"name":"National University Health System, Singapore"},{"name":"Medical Research Foundation, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengku A","family":"Kamalden","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, UM Eye Research Centre, Faculty of Medicine, Universiti Malaya, 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