{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:21:41Z","timestamp":1787761301852,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    The aim of our retrospective study is to report a case series of ocular infections caused by a rare fungus,\n                    <jats:italic toggle=\"yes\">Scedosporium apiospermum<\/jats:italic>\n                    , in a South Indian population. Thirteen cases of culture-positive\n                    <jats:italic toggle=\"yes\">S. apiospermum<\/jats:italic>\n                    infections diagnosed between January 2011 and March 2016 were included in this study. The parameters evaluated were predisposing factors, treatment and final clinical outcome. The most common mode of presentation was keratitis (84.6%) followed by sclerokeratitis (15.3%). The predisposing factors involved were unspecified foreign body injury (30.7%), organic matter injury (15.3%), uncontrolled diabetes (7.6%), and recent manual small-incision cataract surgery (7.6%). Five cases (38.46%) had no predisposing factor. Of the 11 keratitis cases, nine (69.2%) responded well to combination medical therapy while one case (7.6%) required therapeutic keratoplasty. One case was lost to follow-up. Both cases which presented with sclerokeratitis showed no response to medico-surgical treatment progressing to panophthalmitis and evisceration.\n                  <\/jats:p>","DOI":"10.4103\/ijo.ijo_524_17","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T09:45:03Z","timestamp":1514454303000},"page":"137-140","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["Ocular infections caused by Scedosporium apiospermum: A case series"],"prefix":"10.4103","volume":"66","author":[{"given":"Seema","family":"Ramakrishnan","sequence":"first","affiliation":[{"name":"Department of Cornea and Refractive Surgery, Aravind Eye Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Mandlik","sequence":"additional","affiliation":[{"name":"Department of Cornea and Refractive Surgery, Aravind Eye Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejashree Sanket","family":"Sathe","sequence":"additional","affiliation":[{"name":"Department of Cornea and Refractive Surgery, Aravind Eye Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Gubert","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Aravind Eye Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiruvengada","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Cornea and Refractive Surgery, Aravind Eye Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabu","family":"Baskaran","sequence":"additional","affiliation":[{"name":"Department of Vitreo Retina Services, Aravind Eye Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-20251013","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/13693780600752507","article-title":"Scedosporium apiospermum: Changing clinical spectrum of a therapy-refractory opportunist","volume":"44","author":"Guarro","year":"2006","journal-title":"Med Mycol"},{"key":"R3-20251013","first-page":"3","article-title":"Taxonomy of the medical species of Pseudallescheria and Scedosporium","volume":"118","author":"Gu\u00e9ho","year":"1991","journal-title":"J Mycol Med"},{"key":"R4-20251013","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/sj.eye.6700477","article-title":"Scedosporium apiospermum keratomycosis with secondary endophthalmitis","volume":"17","author":"Leck","year":"2003","journal-title":"Eye (Lond)"},{"key":"R5-20251013","doi-asserted-by":"crossref","first-page":"45","DOI":"10.5799\/ahinjs.02.2013.01.0079","article-title":"A case of keratitis caused by Scedosporium apiospermum","volume":"3","author":"\u00d6zkan","year":"2013","journal-title":"J Microbiol Infect Dis"},{"key":"R6-20251013","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.ajo.2004.08.005","article-title":"Bilateral endogenous Scedosporium prolificans endophthalmitis after lung transplantation","volume":"139","author":"Vagefi","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"R7-20251013","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1001\/jamaophthalmol.2013.1497","article-title":"The mycotic ulcer treatment trial: A randomized trial comparing natamycin vs.voriconazole","volume":"131","author":"Prajna","year":"2013","journal-title":"JAMA Ophthalmol"},{"key":"R8-20251013","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1001\/jamaophthalmol.2016.4096","article-title":"Effect of oral voriconazole on fungal keratitis in the mycotic ulcer treatment trial II (MUTT II): A Randomized clinical trial","volume":"134","author":"Prajna","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"R9-20251013","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/ICL.0b013e3181be722e","article-title":"Scedosporium scleritis or keratitis or both: Case series","volume":"35","author":"Jhanji","year":"2009","journal-title":"Eye Contact Lens"},{"key":"R10-20251013","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1097\/ICO.0000000000000969","article-title":"Scedosporium keratitis: An experience from a tertiary eye hospital in South India","volume":"35","author":"Rathi","year":"2016","journal-title":"Cornea"},{"key":"R11-20251013","first-page":"309","article-title":"Efficacy of fluconazole subconjunctival injection as adjunctive therapy for severe recalcitrant fungal corneal ulcer","volume":"91","author":"Isipradit","year":"2008","journal-title":"J Med Assoc Thai"},{"key":"R12-20251013","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1001\/archopht.125.6.789","article-title":"Antimicrobial susceptibility of Fusarium, Aspergillus, and other filamentous fungi isolated from keratitis","volume":"125","author":"Lalitha","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"R13-20251013","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/00003226-199701000-00012","article-title":"Ocular penetration and pharmacokinetics of topical fluconazole","volume":"16","author":"Yee","year":"1997","journal-title":"Cornea"},{"key":"R14-20251013","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1097\/00003226-199711000-00019","article-title":"Fluconazole in filamentous fungal keratitis","volume":"16","author":"Rao","year":"1997","journal-title":"Cornea"},{"key":"R15-20251013","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1007\/s00417-005-1127-8","article-title":"Clinical results of topical fluconazole for the treatment of filamentous fungal keratitis","volume":"244","author":"Sonego-Krone","year":"2006","journal-title":"Graefes Arch Clin Exp Ophthalmol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223307-201866010-00031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:31:20Z","timestamp":1787758280000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223307-201866010-00031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_524_17","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-07-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}