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However, the lesions showed paradoxical worsening and required increased immunosuppression in the form of local steroids and oral immunomodulators. The presence of dual margins of hyperautofluorescence could suggest increased inflammatory activity leading to paradoxical worsening on treatment requiring increased immunosuppression.<\/jats:p>","DOI":"10.4103\/ijo.ijo_536_19","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:59:49Z","timestamp":1582160389000},"page":"536-538","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Dual lesion margins on fundus autofluorescence associated with paradoxical worsening following treatment for tubercular serpiginous-like choroiditis"],"prefix":"10.4103","volume":"68","author":[{"given":"Sai Bhakti","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Retina and Uveitis, GMR Varalakshmi Campus, L V Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketan","family":"Saoji","sequence":"additional","affiliation":[{"name":"Department of Retina and Uveitis, GMR Varalakshmi Campus, L V Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Pathengay","sequence":"additional","affiliation":[{"name":"Department of Retina and Uveitis, GMR Varalakshmi Campus, L V Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,2,14]]},"reference":[{"key":"R1-20251013","first-page":"121","article-title":"Pattern of uveitis in a referral eye clinic in north India","volume":"52","author":"Singh","year":"2004","journal-title":"Indian J Ophthalmol"},{"key":"R2-20251013","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.ajo.2011.05.004","article-title":"Continuous progression of tubercular serpiginous-like choroiditis after initiating antituberculosis treatment","volume":"152","author":"Gupta","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"R3-20251013","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/eye.2008.204","article-title":"Jarisch-Herxheimer reaction: Paradoxical worsening of tuberculosis chorioretinitis following initiation of antituberculous therapy","volume":"23","author":"Cheung","year":"2009","journal-title":"Eye (Lond)"},{"key":"R4-20251013","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.survophthal.2007.08.015","article-title":"Intraocular tuberculosis \u2013 An update","volume":"52","author":"Gupta","year":"2007","journal-title":"Surv Ophthalmol"},{"key":"R5-20251013","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.ophtha.2009.02.005","article-title":"Diagnosis of tuberculous uveitis: Clinical application of an interferon-gamma release assay","volume":"116","author":"Ang","year":"2009","journal-title":"Ophthalmology"},{"key":"R6-20251013","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12886-017-0597-x","article-title":"What does IGRA testing add to the diagnosis of ocular tuberculosis? 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