{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:33:57Z","timestamp":1786739637903,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Therapeutic contact lenses (TCL) are known to help in epithelial healing and decreasing pain after various corneal surgeries. However, literature lacks any data describing their use following Descemet's stripping automated endothelial keratoplasty (DSAEK) where intraoperative epithelial debridement is commonly performed. Here we study the efficacy and safety of TCL in patients undergoing DSAEK.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this prospective, randomized, controlled clinical trial. 40 eyes of 40 patients of pseudophakic bullous keratopathy undergoing DSAEK were enrolled and randomized into two groups, control (no TCL) and test (TCL). Primary outcome was time taken for epithelial healing and secondary outcomes were postoperative pain score, graft attachment, best spectacle-corrected visual acuity, and endothelial cell loss at 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Average time taken for epithelial healing was 3.35 \u00b1 0.49 days in the test group and 4.95 \u00b1 1.05 days in the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Average pain scores in first operative week were significantly lower in the test group as compared to control (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Graft detachment occurred in eight patients in control group and two in test group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03). Both rebubbling rates and average endothelial cell loss at 3 months were higher in the control group with\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.07 and 0.06 respectively. No contact lens-related adverse effects were noted during the study period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Use of TCL in DSAEK leads to faster epithelial healing and lesser postoperative pain. In addition, it may also contribute to lower rebubbling rates and endothelial cell loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_538_20","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T08:27:00Z","timestamp":1608020820000},"page":"75-81","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Role of therapeutic contact lens following Descemet's stripping automated endothelial keratoplasty"],"prefix":"10.4103","volume":"69","author":[{"given":"Ritika","family":"Mukhija","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prafulla K","family":"Maharana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelima","family":"Aron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Satpathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeewan S","family":"Titiyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20-20240828","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.ophtha.2007.09.005","article-title":"Endothelial keratoplasty a simplified technique to minimize graft dislocation, iatrogenic graft failure, and pupillary block","volume":"115","author":"Terry","year":"2008","journal-title":"Ophthalmology"},{"key":"R2-20-20240828","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/ICU.0000000000000073","article-title":"Evolving indications for Descemet's stripping automated endothelial keratoplasty","volume":"25","author":"Veldman","year":"2014","journal-title":"Curr Opin 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