{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:35:31Z","timestamp":1792625731622,"version":"4.5.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare operative outcomes of patients after canaloplasty and trabeculectomy with mitomycin C (MMC) through 2-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We included 31 eyes of 31 patients with primary open-angle glaucoma (POAG) who underwent canaloplasty and 37 eyes of 37 patients with POAG who underwent trabeculectomy with MMC with 24 months of postoperative follow-up. All surgeries were performed by a single surgeon between January 2005 and May 2011. Failure was defined as intraocular pressure (IOP &gt;18 or &lt;4 mmHg at 2 years), second operative procedure, or loss of light perception. Change in IOP, visual acuity (VA), glaucoma medications, and complication rates at 24 months were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Caucasians made up to half of the patients included in this study (58% vs. 43%) while the rest where either African Americans (32% vs. 43%) or Hispanic (10% vs. 14%) patients between the canaloplasty and trabeculectomy group. Both groups showed significant reduction in IOP from baseline at 24 months. Trabeculectomy patients had a greater mean reduction of IOP compared to canaloplasty patients (12.2 \u00b1 12 vs. 4.7 \u00b1 7.5,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003) and also achieved lower IOP at 24 months (12.2 \u00b1 4.1 vs. 14.9 \u00b1 6.0,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03). Postoperative glaucoma medication use was less in the trabeculectomy group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 0, interquartile range [IQR] 0\u20132) compared to those in whom canaloplasty was performed (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2, IQR 0\u20133,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02). VA showed no statistical change in either group over 2 years. Overall failure rates at 2 years were comparable between the two groups: 32% for trabeculectomy and 26% for canaloplasty (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.6). Subgroup analysis revealed a lower failure rate in Caucasions (15%) when compared to Blacks (42%) and Hispanics\/others (50%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Canaloplasty and trabeculectomy both achieved significant reduction in IOP with comparable success rates. Trabeculectomy can achieve a greater reduction in IOP while requiring fewer medications however is associated with more intensive postoperative care and frequent interventions. Pigmented populations have worse outcomes compared to Caucasians.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_543_17","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T09:45:03Z","timestamp":1514454303000},"page":"66-70","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["Comparison of surgical outcomes between canaloplasty and trabeculectomy with mitomycin C at 2-year follow-up: A longitudinal cohort study"],"prefix":"10.4103","volume":"66","author":[{"given":"Winston J","family":"Garris","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Tulane School of Medicine, Tulane University, New Orleans, Louisiana, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tulane School of Medicine, Tulane University, New Orleans, Louisiana, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zurakowski","sequence":"additional","affiliation":[{"name":"Departments of Anesthesia and Surgery, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh S","family":"Ayyala","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tulane School of Medicine, Tulane University, New Orleans, Louisiana, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251013","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.jcrs.2007.03.051","article-title":"Canaloplasty: Circumferential viscodilation and tensioning of Schlemm's canal using a flexible microcatheter for the treatment of open-angle glaucoma in adults: Interim clinical study analysis","volume":"33","author":"Lewis","year":"2007","journal-title":"J Cataract Refract Surg"},{"key":"R2-20251013","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1016\/j.ophtha.2011.05.021","article-title":"Comparison of surgical outcomes between canaloplasty and trabeculectomy at 12 months\u2019 follow-up","volume":"118","author":"Ayyala","year":"2011","journal-title":"Ophthalmology"},{"key":"R3-20251013","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/IJG.0000000000000023","article-title":"Comparison of surgical outcomes between phacocanoloplasty and phacotrabeculectomy at 12 months\u2019 follow-up: A longitudinal cohort study","volume":"24","author":"Schoenberg","year":"2015","journal-title":"J Glaucoma"},{"key":"R4-20251013","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/IJG.0b013e318255bb30","article-title":"Intraindividual comparison of canaloplasty versus trabeculectomy with Mitomycin C in a single-surgeon series","volume":"22","author":"Br\u00fcggemann","year":"2013","journal-title":"J Glaucoma"},{"key":"R5-20251013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2415-13-1","article-title":"Comparison of phacotrabeculectomy versus phacocanaloplasty in the treatment of patients with concomitant cataract and glaucoma","volume":"13","author":"Matlach","year":"2013","journal-title":"BMC Ophthalmol"},{"key":"R6-20251013","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/aos.12722","article-title":"Trabeculectomy versus canaloplasty (TVC study) in the treatment of patients with open-angle glaucoma: A prospective randomized clinical trial","volume":"93","author":"Matlach","year":"2015","journal-title":"Acta Ophthalmol"},{"key":"R7-20251013","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/IJG.0000000000000103","article-title":"Canaloplasty in open-angle glaucoma: Mid-term results from a multicenter study","volume":"25","author":"Brusini","year":"2016","journal-title":"J Glaucoma"},{"key":"R11-20251013","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00061198-200106000-00017","article-title":"Trabeculectomy, risk factors for failure and the preoperative state of the conjunctiva","volume":"10","author":"Broadway","year":"2001","journal-title":"J Glaucoma"},{"key":"R12-20251013","first-page":"753","article-title":"Conjunctival advancement with subconjunctival amniotic membrane draping technique for leaking cystic blebs","volume":"93","author":"Sethi","year":"2015","journal-title":"J Glaucoma"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223307-201866010-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:31:05Z","timestamp":1787758265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223307-201866010-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_543_17","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-07-10","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}