{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:21:41Z","timestamp":1787761301771,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The purpose of this study is to report on the efficacy and safety of topical chemotherapy alone for giant ocular surface squamous neoplasia (OSSN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this retrospective, interventional series, 10 eyes with giant OSSN underwent exfoliative biopsy to confirm the diagnosis followed by application of interferon alpha 2b (IFN \u03b12b) and\/or 5 fluorouracil, 1% (5FU). Reported outcome measures were tumor response, visual acuity, recurrence, systemic metastasis, and treatment complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Ten patients (3 female, 7 male) had a mean age of 73 (median, 69; range 40\u201389) years. Mean tumor diameter was 13.1 (median, 12.3; range 8.2\u201319.4) mm. Five (50%) eyes were treated with IFN-\u03b12b alone; 1 (10%) with 5-FU alone and 4 (40%) required both IFN-\u03b12b and 5-FU. The mean duration of treatment was 3, 0.5, and 6.4 months for IFN-\u03b12b alone, 5-FU alone, and both IFN-\u03b12b and 5-FU respectively. Complete tumor response was observed in all 10 cases at mean follow-up of 12.8 (median, 11.5; range, 3\u201325) months. Complications noted were transient irritation and burning (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 4), dry eyes (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2), and transient flu-like symptoms (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2). There was no evidence of chemotherapy-related symblepharon, stem cell deficiency, scleral thinning, or corneal opacity. There were no tumor recurrences, and no patient required surgical excision or cryotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Topical chemotherapy was a safe and effective treatment, inducing complete regression in all cases of giant OSSN in this series. There were no sight-limiting complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_590_17","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T09:45:03Z","timestamp":1514454303000},"page":"55-60","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":32,"title":["Topical chemotherapy for giant ocular surface squamous neoplasia of the conjunctiva and cornea: Is surgery necessary?"],"prefix":"10.4103","volume":"66","author":[{"given":"Sonal S","family":"Chaugule","sequence":"first","affiliation":[{"name":"Department of Ocular Tumor and Orbital Disease, The New York Eye Cancer Center, New York, NY, USA"},{"name":"Department of Ophthalmology, The New York Eye and Ear Infirmary of Mt. 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