{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:20:31Z","timestamp":1787757631981,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To describe the clinical profile and demographic distribution of Terrien\u2019s marginal degeneration (TMD) in patients presenting to a multitier ophthalmology hospital network in India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This cross-sectional hospital-based study included 2,470,793 new patients presenting between September 2012 and September 2020 (~8 years period). Patients with a clinical diagnosis of TMD in at least one eye were included as cases. The data were collected using an electronic medical record system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Overall, 184 (0.007%) new patients were diagnosed. Over half of patients were males (56.52%) with bilateral affliction (54.89%). The mean age of the patients was 38.63 \u00b1 16.75 years. Majority (28.26%) of the patients were between 21 and 30 years of age bracket. The number of patients were from rural and urban districts were comparable (41.85% vs. 48.37%). The most common clinical signs were ectasia\/thinning (50.53%), corneal scar (44.21%), and prominent nerves (5.26%). Associated ocular comorbidities included vernal keratoconjunctivitis in 6 (2.11%) eyes, meibomitis in 6 (9.7%) eyes, squamous blepharitis in 2 (3.2%) eyes, dry eye in 2 (3.2%) eyes, cataract in 46 (74.2%) eyes, and glaucoma in 6 (9.7%) eyes. Most of the eyes had mild or no visual impairment (43.86%). Two (0.7%) eyes had spontaneous perforation patients. None of patients had hydrops in the years of follow-up. Keratoplasty was performed in 3.86%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>TMD is a rare disease affecting patients seeking eye care at the ophthalmology network. It commonly affects adult males and is predominantly bilateral. The disease progression is slow, and risk of spontaneous perforation was low. At initial presentation, visual impairment was mild to moderate in majority and the most common surgical intervention was cataract surgery during the study period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_609_21","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T06:54:59Z","timestamp":1638255299000},"page":"3482-3486","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Clinical profile and demographic distribution of Terrien\u2019s marginal degeneration in a multitier ophthalmology network in India"],"prefix":"10.4103","volume":"69","author":[{"given":"Anthony V","family":"Das","sequence":"first","affiliation":[{"name":"Department of eyeSmart EMR and AEye, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimeshika L","family":"Pillutla","sequence":"additional","affiliation":[{"name":"Department of eyeSmart EMR and AEye, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Chaurasia","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment Services, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"B1-20240828","first-page":"12","article-title":"Dystrophie marginale symetrique des deux cornees avec astimgatisme regulier consequetif et guerison par la cauterisation ignee","volume":"20","author":"Terrien","year":"1900","journal-title":"Arch Ophthalmol (Paris)"},{"key":"B2-20240828","first-page":"931","article-title":"Peripheral corneal grafts in Terrien's marginal degeneration","volume":"14","author":"Brown","year":"1983","journal-title":"Ophthalmic Surg"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.survophthal.2018.09.004","article-title":"Terrien marginal degeneration","volume":"64","author":"Ding","year":"2019","journal-title":"Surv Ophthalmol"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"396","DOI":"10.4103\/0301-4738.100533","article-title":"Integrated model of primary and secondary eye care for underserved rural areas:The L V Prasad Eye Institute experience","volume":"60","author":"Rao","year":"2012","journal-title":"Indian J Ophthalmol"},{"key":"B6-20240828","doi-asserted-by":"crossref","first-page":"427","DOI":"10.4103\/ijo.IJO_710_19","article-title":"Big data and the eyeSmart electronic medical record system - An 8-year experience from a three-tier eye care network in India","volume":"68","author":"Das","year":"2020","journal-title":"Indian J Ophthalmol"},{"key":"B7-20240828","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s10792-020-01326-3","article-title":"Clinical profile of pterygium in patients seeking eye care in India:Electronic medical records-driven big data analytics report III","volume":"40","author":"Das","year":"2020","journal-title":"Int Ophthalmol"},{"key":"B10-20240828","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.ajo.2015.07.031","article-title":"Terrien marginal degeneration:Clinical characteristics and outcomes","volume":"160","author":"Chan","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"B11-20240828","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0002-9394(81)90768-6","article-title":"Inflammatory Terrien's marginal corneal disease","volume":"92","author":"Austin","year":"1981","journal-title":"Am J Ophthalmol"},{"key":"B12-20240828","doi-asserted-by":"crossref","first-page":"432","DOI":"10.4103\/ijo.IJO_1474_19","article-title":"Commentary:Electronic medical record system-should complement but not replace traditional healthcare","volume":"68","author":"Kumar","year":"2020","journal-title":"Indian J Ophthalmol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_609_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:47:21Z","timestamp":1787755641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_609_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,26]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_609_21","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,26]]},"assertion":[{"value":"2021-03-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}