{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:41:51Z","timestamp":1791250911238,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To observe the changes in corneal epithelial thickness after FS-LASIK and Trans-PRK surgery and to investigate the impact of corneal epithelial remodeling on Q-value and HOA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this prospective cohort study, 50 patients (100 eyes) underwent FS-LASIK and 45 patients (90 eyes) underwent Trans-PRK. Anterior segment OCT was used to measure the corneal epithelial thickness in different corneal zones (central zone: 0\u20132 mm; paracentral zone: 2\u20135 mm; and mid-peripheral zone: 5\u20136 mm) preoperatively and postoperatively at 1 week, 1 month, 3 months, and 6 months. The correlation between \u25b3CET in the superior, nasal, inferior, and temporal region at 6 months postoperatively and \u25b3Q and \u25b3HOA was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At 6 months postoperatively, the epithelial thickness increased in the central, paracentral, and mid-peripheral zones in FS-LASIK and Trans-PRK. Central epithelial thickness and different regions of the paracentral zone and mid-peripheral exhibited significant thickening (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). In the para-central zone and mid-peripheral zone, the \u25b3CET in different regions after LASIK and Trans-PRK was positively correlated with \u25b3Q (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) and \u25b3HOA (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>After FS-LASIK and Trans-PRK, significant epithelial thickening was observed. Epithelial changes in different regions lead to different Q-values in different regions and have different effects on HOA. This has a certain guiding significance for the design of refractive surgery, and minimizing the increase of Q-value may improve the postoperative visual quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_623_24","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T03:00:32Z","timestamp":1734922832000},"page":"134-140","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Effects of corneal epithelial remodeling on corneal asphericity after FS-LASIK and Trans-PRK: A prospective study"],"prefix":"10.4103","volume":"73","author":[{"given":"Mingyu","family":"Xu","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin, China"},{"name":"Tianjin Branch of National Clinical Research Center for Ocular Disease, Tianjin, China"},{"name":"Eye Institute and School of Optometry, Tianjin, China"},{"name":"Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin, China"},{"name":"Tianjin Branch of National Clinical Research Center for Ocular Disease, Tianjin, China"},{"name":"Eye Institute and School of Optometry, Tianjin, China"},{"name":"Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel Eric","family":"Pazo","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin, China"},{"name":"Tianjin Branch of National Clinical Research Center for Ocular Disease, Tianjin, China"},{"name":"Eye Institute and School of Optometry, Tianjin, China"},{"name":"Tianjin Medical University Eye Hospital, Tianjin, 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