{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:00:51Z","timestamp":1791961251619,"version":"4.3.4"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Many studies include elevated activity of angiotensin-converting enzyme (ACE) in serum in sarcoidosis and in ocular sarcoidosis as well, but there are only a few analyzing ACE activities in aqueous humor. The aim of this study is to illuminate the diagnostic value of ACE in aqueous humor in patients with ocular sarcoidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed twenty patients with ocular sarcoidosis and 18 patients with nonocular involvement. All patients have biopsy-positive sarcoidosis of the lungs and\/or mediastinal lymph nodes. Blood samples for ACE serum levels were obtained from all patients. Aqueous humor samples were taken by paracentesis with a 25-gauge needle in local anesthesia. With appropriate statistical tests, we compared ACE activity in serum and aqueous humor in patients with and without ocular sarcoidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The majority of our patients with ocular sarcoidosis were female (12\/20), also in the group with systemic sarcoidosis and without ocular involvement (12\/6). Mean age of the whole analyzed group of sarcoidosis patients was 45 \u00b1 6 years. There is no statistically significant difference in ACE activity in serum between two groups of patients (with and without ocular sarcoidosis). There is statistically significant difference in ACE activity in aqueous humor among patients with ocular and nonocular sarcoidosis. ACE activity in aqueous humor is significantly higher in patients with ocular sarcoidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Increased ACE activity in aqueous humor can point to a diagnosis of ocular sarcoidosis, without the need for ocular biopsy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_645_16","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T08:58:30Z","timestamp":1508230710000},"page":"979-983","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Utility of angiotensin-converting enzyme activity in aqueous humor in the diagnosis of ocular sarcoidosis"],"prefix":"10.4103","volume":"65","author":[{"given":"Violeta","family":"Mihailovic-Vucinic","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"},{"name":"Clinic for Pulmonary Diseases, Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljubica","family":"Popevic","sequence":"additional","affiliation":[{"name":"Health Care Center Vo\u017edovac, Ophthalmology Unit, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spasoje","family":"Popevic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"},{"name":"Clinic for Pulmonary Diseases, Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihailo","family":"Stjepanovic","sequence":"additional","affiliation":[{"name":"Clinic for Pulmonary Diseases, Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andjelka","family":"Aleksic","sequence":"additional","affiliation":[{"name":"Department of Statistics, Institute of Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anka","family":"Stanojevic-Paovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251013","first-page":"135","article-title":"Diagnostic management of patients with suspected ocular sarcoidosis","volume":"5","author":"Takada","year":"2013","journal-title":"J Thorac Dis"},{"key":"R2-20251013","first-page":"1261","article-title":"Clinical manifestations and outcomes of ocular sarcoidosis in Saudi Arabia","volume":"8","author":"Shoughy","year":"2015","journal-title":"Int J Ophthalmol"},{"key":"R3-20251013","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1136\/bjo.48.9.461","article-title":"Ocular Sarcoidosis","volume":"48","author":"James","year":"1964","journal-title":"Br J Ophthalmol"},{"key":"R4-20251013","first-page":"181","article-title":"Low prevalence of uveitis in Italian sarcoidosis patients","volume":"8","author":"Angi","year":"1991","journal-title":"Sarcoidosis"},{"key":"R5-20251013","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/0002-9394(78)90184-8","article-title":"Sarcoidosis and its ophthalmic manifestations","volume":"86","author":"Obenauf","year":"1978","journal-title":"Am J Ophthalmol"},{"key":"R6-20251013","first-page":"736","article-title":"Statement on sarcoidosis. 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