{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:09:19Z","timestamp":1788962959869,"version":"build-2803163510"},"reference-count":91,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Corneal collagen cross-linking has become the preferred modality of treatment for corneal ectasia since its inception in late 1990s. Numerous studies have demonstrated the safety and efficacy of the conventional protocol. Our understanding of the cross-linking process is ever evolving, with its wide implications in the form of accelerated and pulsed protocols. Newer advancements in technology include various riboflavin formulations and the ability to deliver higher fluence protocols with customised irradiation patterns. A greater degree of customisation is likely the path forward, which will aim at achieving refractive improvements along with disease stability. The use of cross-linking for myopic correction is another avenue under exploration. Combination of half fluence cross-linking with refractive correction for high errors to prevent post LASIK regression is gaining interest. This review aims to highlight the various advancements in the cross-linking technology and its clinical applications.<\/jats:p>","DOI":"10.4103\/ijo.ijo_648_17","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T23:17:01Z","timestamp":1505776621000},"page":"787-796","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":29,"title":["Recent advances in corneal collagen cross-linking"],"prefix":"10.4103","volume":"65","author":[{"given":"Gitansha Shreyas","family":"Sachdev","sequence":"first","affiliation":[{"name":"Dr. Gitansha Shreyas Sachdev, The Eye Foundation, Coimbatore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahipal","family":"Sachdev","sequence":"additional","affiliation":[{"name":"Centre for Sight, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251013","first-page":"2019","article-title":"Keratoconus: Current perspectives","volume":"7","author":"Vazirani","year":"2013","journal-title":"Clin Ophthalmol"},{"key":"R2-20251013","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/exer.1997.0410","article-title":"Induction of cross-links in corneal tissue","volume":"66","author":"Spoerl","year":"1998","journal-title":"Exp Eye Res"},{"key":"R3-20251013","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1167\/iovs.11-8059","article-title":"Optimization model for UV-riboflavin corneal cross-linking","volume":"53","author":"Schumacher","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R4-20251013","first-page":"30","article-title":"Computer modelling study of corneal cross-linking with riboflavin","volume":"53","author":"Pertaub","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R5-20251013","doi-asserted-by":"crossref","first-page":"9174","DOI":"10.1167\/iovs.11-7395","article-title":"Patient-specific computational modeling of keratoconus progression and differential responses to collagen cross-linking","volume":"52","author":"Roy","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R6-20251013","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","article-title":"Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus","volume":"135","author":"Wollensak","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"R7-20251013","first-page":"306","article-title":"Photochemical researches \u2013 Part V. 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