{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:17:04Z","timestamp":1790036224662,"version":"4.0.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"\n Purpose:<\/jats:title>\n This prospective study aimed to assess the impact of topical latanoprost 0.005% treatment on the microvasculature of the macula and optic nerve head (ONH) in primary open-angle glaucoma (POAG).<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Fifty-seven eyes of 31 subjects were enrolled. ONH whole-image (wiVD), peripapillary (ppVD), and macular vascular density (VD) parameters were measured using optical coherence tomography angiography before treatment, at the 1\n st<\/jats:sup>\n month, and at the 3\n rd<\/jats:sup>\n month of treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n There was a significant reduction in IOP post treatment, with a decrease of 17.0 \u00b1 2.3 mmHg in the 1\n st<\/jats:sup>\n month and 16.3 \u00b1 2.5 mmHg in the 3\n rd<\/jats:sup>\n month (\n P<\/jats:italic>\n < 0.001 for both). ONH wiVD and ppVD significantly increased at the post-treatment 1\n st<\/jats:sup>\n month (\n P<\/jats:italic>\n = 0.001 for both) but decreased by the 3\n rd<\/jats:sup>\n month, returning to baseline levels (\n P<\/jats:italic>\n < 0.001 for both), indicating a return to pre-treatment levels (\n P<\/jats:italic>\n > 0.05 for both). Similarly, macular wiVD and perifoveolar VD (pefVD) increased significantly at the 1\n st<\/jats:sup>\n month (\n P<\/jats:italic>\n = 0.013 and\n P<\/jats:italic>\n < 0.001, respectively) but returned to baseline by the 3\n rd<\/jats:sup>\n month (\n P<\/jats:italic>\n < 0.001 for both). No significant difference was observed between before-treatment and post-treatment 3\n rd<\/jats:sup>\n month regarding the macular wiVD and pefVD (\n P<\/jats:italic>\n > 0.05 for both). Deep capillary plexus and foveal avascular zone parameters did not change during follow-up (\n P<\/jats:italic>\n > 0.05 for both).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n The initial increase in ONH and peripapillary VD, as well as macular VD, is attributed to the acute reduction in IOP from topical latanoprost 0.005%. However, the diminishment of sustained differences by the 3\n rd<\/jats:sup>\n month indicates adaptation of the ONH and retinal microvasculature to decreased IOP through compensatory mechanisms.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_648_24","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:01:20Z","timestamp":1761235280000},"page":"S907-S912","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The effects of topical latanoprost 0.005% treatment on microvascular changes in the optic nerve head and macula"],"prefix":"10.4103","volume":"72","author":[{"given":"B\u00fc\u015fra D","family":"Y\u0131ld\u0131r\u0131m Erdal","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6zde","family":"Hondur","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Bayraktar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Elgin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"\u015een","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"R1-20260426","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"R2-20260426","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/S0140-6736(17)31469-1","article-title":"Glaucoma","volume":"390","author":"Jonas","year":"2017","journal-title":"Lancet"},{"key":"R3-20260426","doi-asserted-by":"crossref","first-page":"P71","DOI":"10.1016\/j.ophtha.2020.10.022","article-title":"American Academy of Ophthalmology Preferred Practice Pattern Glaucoma Panel. 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