{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:59:01Z","timestamp":1788965941488,"version":"build-2803163510"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"\n Purpose:<\/jats:title>\n The aim of this study was to evaluate retinal nerve fiber layer (RNFL), radial peripapillary capillary plexus (RPCP), and lamina cribrosa (LC) parameters in patients diagnosed with obstructive sleep apnea syndrome (OSAS) and healthy controls and to investigate the relationship between these parameters and OSAS severity.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This prospective case-control study included 124 eyes from 124 OSAS patients (mild: n = 24, moderate: n = 45, severe: n = 55) diagnosed by polysomnography and 104 eyes of 104 healthy individuals. RNFL thickness, ganglion cell-inner plexiform layer (GCIPL) thickness, RPCP vessel densities (VD), LC thickness (LCT), LC depth, LC anterior width, LC curvature depth, and LC curvature index (LCCI) were assessed using swept-source optical coherence tomography and optical coherence tomography angiography. Comparisons among groups and correlation analyses were performed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n RNFL thickness and RPCP VD were significantly lower in OSAS patients compared to healthy controls (\n P<\/jats:italic>\n < 0.05). No significant differences were observed among groups in GCIPL thickness. Among LC parameters, LCCI was significantly higher in severe and moderate OSAS groups compared to healthy controls (\n P<\/jats:italic>\n < 0.05). Moreover, a positive correlation was found between apnea-hypopnea index and LCCI, while a negative correlation was noted between AHI and LCT (\n P<\/jats:italic>\n = 0.013 and\n P<\/jats:italic>\n = 0.005, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n LC parameters, particularly LCCI, may serve as important indicators reflecting disease severity and potential structural alterations at the optic nerve head in OSAS patients. LCCI may have clinical utility in assessing early optic neuropathy risk in OSAS. Further large-scale, prospective studies are warranted to validate these findings.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_652_25","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:00:34Z","timestamp":1758801634000},"page":"1443-1448","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Lamina cribrosa curvature index as a biomarker of non-glaucomatous optic neuropathy in obstructive sleep apnea syndrome"],"prefix":"10.4103","volume":"73","author":[{"given":"Serhat","family":"Ermis","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ece","family":"Ozal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idil Celen","family":"Arabaci","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulku Dubus","family":"Hos","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cengiz","family":"Gul","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Karapapak","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sad\u0131k Altan","family":"Ozal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"R1-20260420","first-page":"1741","article-title":"Structural assessment of the optic nerve in patients with obstructive sleep apnea syndrome: Case-control study","volume":"31","author":"Uslu","year":"2021","journal-title":"Eur J Ophthalmol"},{"key":"R2-20260420","first-page":"1552","article-title":"Peripapillary choroidal thickness and retinal nerve fiber layer in untreated patients with obstructive sleep apnea-hypopnea syndrome: A case-control study","volume":"42","author":"Yazgan","year":"2017","journal-title":"Curr Eye Res"},{"key":"R3-20260420","first-page":"85","article-title":"A clinical approach to obstructive sleep apnea as a risk factor for cardiovascular disease","volume":"12","author":"Maeder","year":"2016","journal-title":"Vasc Health Risk Manag"},{"key":"R4-20260420","first-page":"597","article-title":"Rules for scoring respiratory events in sleep: Update of the 2007 AASM Manual for the scoring of sleep and associated events. deliberations of the sleep apnea definitions task force of the American Academy of Sleep Medicine","volume":"8","author":"Berry","year":"2012","journal-title":"J Clin Sleep Med"},{"key":"R5-20260420","first-page":"453","article-title":"Evaluation of retinal nerve fiber layer, ganglion cell layer, and optic nerve head morphological parameters in patients with obstructive sleep apnea and comparison with normal population","volume":"70","author":"Sundaram","year":"2022","journal-title":"Indian J Ophthalmol"},{"key":"R6-20260420","first-page":"454","article-title":"Obstructive sleep apnea and ocular disorders","volume":"21","author":"Grover","year":"2010","journal-title":"Curr Opin Ophthalmol"},{"key":"R7-20260420","first-page":"42","article-title":"Prevalence of normal tension glaucoma in obstructive sleep apnea syndrome patients","volume":"16","author":"Sergi","year":"2007","journal-title":"J Glaucoma"},{"key":"R8-20260420","first-page":"575","article-title":"Retinal nerve fibre layer measurements are reduced in patients with obstructive sleep apnoea syndrome","volume":"19","author":"Kargi","year":"2005","journal-title":"Eye (Lond)"},{"key":"R9-20260420","first-page":"1009","article-title":"High prevalence of glaucoma in patients with sleep apnea syndrome","volume":"106","author":"Mojon","year":"1999","journal-title":"Ophthalmology"},{"key":"R10-20260420","first-page":"4034382","article-title":"Alterations in parafoveal and optic disc vessel densities in patients with obstructive sleep apnea syndrome","volume":"2020","author":"Ucak","year":"2020","journal-title":"J Ophthalmol"},{"key":"R11-20260420","first-page":"223","article-title":"Evaluation of retinal nerve fiber layer thickness and optic nerve head parameters in obstructive sleep apnoea patients","volume":"35","author":"Ngoo","year":"2021","journal-title":"Korean J Ophthalmol"},{"key":"R12-20260420","first-page":"3065","article-title":"Obstructive sleep apnoea and glaucoma: A systematic review and meta-analysis","volume":"37","author":"Cheong","year":"2023","journal-title":"Eye (Lond)"},{"key":"R13-20260420","first-page":"19","article-title":"Ocular manifestations of obstructive sleep apnea: A systematic review and meta-analysis","volume":"262","author":"Bulloch","year":"2024","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R14-20260420","first-page":"1","article-title":"Meta-analysis of association of obstructive sleep apnea with glaucoma","volume":"25","author":"Liu","year":"2016","journal-title":"J Glaucoma"},{"key":"R15-20260420","first-page":"265","article-title":"Sleep apnea and eye diseases: Evidence of association and potential pathogenic mechanisms","volume":"18","author":"Garc\u00eda-S\u00e1nchez","year":"2022","journal-title":"J Clin Sleep Med"},{"key":"R16-20260420","first-page":"1145","article-title":"The association between ophthalmologic diseases and obstructive sleep apnea: A systematic review and meta-analysis","volume":"20","author":"Huon","year":"2016","journal-title":"Sleep Breath"},{"key":"R17-20260420","first-page":"585","article-title":"Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea\/hypopnea syndrome","volume":"249","author":"Lin","year":"2011","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R18-20260420","first-page":"3506","article-title":"Reduced retinal vessel density in obstructive sleep apnea syndrome patients: An optical coherence tomography angiography study","volume":"58","author":"Yu","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R19-20260420","first-page":"e456","article-title":"The relationship between obstructive sleep apnea syndrome and glaucoma","volume":"98","author":"Moyal","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"R20-20260420","first-page":"2824","article-title":"Continuous intraocular pressure monitoring during nocturnal sleep in patients with obstructive sleep apnea syndrome","volume":"57","author":"Shinmei","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R21-20260420","first-page":"e156","article-title":"Obstructive sleep apnea in primary open angle glaucoma patients","volume":"28","author":"Moghimi","year":"2019","journal-title":"J Glaucoma"},{"key":"R22-20260420","first-page":"755","article-title":"Diagnostic power of lamina cribrosa depth and curvature in glaucoma","volume":"58","author":"Lee","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R23-20260420","first-page":"44","article-title":"Comparison between lamina cribrosa depth and curvature as a predictor of progressive retinal nerve fiber layer thinning in primary open-angle glaucoma","volume":"1","author":"Lee","year":"2018","journal-title":"Ophthalmol Glaucoma"},{"key":"R24-20260420","first-page":"163","article-title":"Comparative analysis of lamina parameters in non-glaucomatous eyes with and without pseudoexfoliation syndrome","volume":"274","author":"Jung","year":"2025","journal-title":"Am J Ophthalmol"},{"key":"R24-20260420","article-title":"Erratum","year":"2025","journal-title":"Am J Ophthalmol"},{"key":"R25-20260420","first-page":"e14422","article-title":"Impaired blood flow of optic nerve head in patients with severe obstructive sleep apnea\/hypopnea syndrome","volume":"34","author":"Lin","year":"2025","journal-title":"J Sleep Res"},{"key":"R26-20260420","first-page":"1235","article-title":"Parafoveal and optic disc vessel density in patients with obstructive sleep apnea syndrome: An optical coherence tomography angiography study","volume":"256","author":"Moyal","year":"2018","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R27-20260420","first-page":"1459","article-title":"Correlation between structural progression in glaucoma and obstructive sleep apnea","volume":"33","author":"Fan","year":"2019","journal-title":"Eye (Lond)"},{"key":"R28-20260420","first-page":"47","article-title":"Prospective evaluation of the comorbidity of obstructive sleep apnea in patients with glaucoma","volume":"18","author":"Chan","year":"2022","journal-title":"J Clin Sleep Med"},{"key":"R29-20260420","first-page":"1","article-title":"Is obstructive sleep apnea associated with progressive glaucomatous optic neuropathy?","volume":"27","author":"Swaminathan","year":"2018","journal-title":"J Glaucoma"},{"key":"R30-20260420","first-page":"692","article-title":"Lamina cribrosa morphology in glaucomatous eyes with hemifield defect in a Korean Population","volume":"126","author":"Kim","year":"2019","journal-title":"Ophthalmology"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_652_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:26:00Z","timestamp":1786724760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_652_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,25]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_652_25","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,25]]},"assertion":[{"value":"2025-03-10","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}