{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:06:14Z","timestamp":1787169974116,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To present a selected case series of advanced glaucoma-associated peripapillary and macular retinoschisis and response to various treatment strategies with a comprehensive literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective observational case series. Retrospective review of five selected cases of advanced glaucoma with peripapillary and macular retinoschisis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All five patients had advanced glaucomatous damage with macular and peripapillary retinoschisis, three (patients 2, 3, and 5) had a neurosensory detachment of the macula. Increased intraocular pressure was managed with maximal antiglaucoma medications and G6 micropulse diode laser treatment in the first patient, transscleral diode laser in the second patient, mitomycin-C augmented trabeculectomy in the third patient, maximal antiglaucoma medications alone in the fourth patient, pars plana vitrectomy followed by trabeculectomy in the fifth patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We speculate that peripapillary and macular retinoschisis may indicate a vision-threatening sequelae of advanced glaucoma. The probable inciting factor for this vision-threatening pathology being elevated intraocular pressure, fluctuations in intraocular pressure, and chronic glaucoma with advanced cupping. We emphasize that meticulous examination of the macula in patients with advanced glaucoma is mandatory. It is imperative to do OCT macula in patients with advanced glaucoma to diagnose this distinct entity at an earlier stage and preserve the existing visual potential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_668_21","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T06:54:59Z","timestamp":1638255299000},"page":"3552-3558","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Peripapillary and macular retinoschisis - A vision-threatening sequelae of advanced glaucomatous cupping"],"prefix":"10.4103","volume":"69","author":[{"given":"Vijayalakshmi A","family":"Senthilkumar","sequence":"first","affiliation":[{"name":"Department of Glaucoma, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitaranjan","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Retina and Vitreoretinal Surgery, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh B","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Retina and Vitreoretinal Surgery, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"E205","DOI":"10.1097\/OPX.0b013e3181d1dad5","article-title":"Peripapillary schisis with serous detachment in advanced glaucoma","volume":"87","author":"Farjad","year":"2010","journal-title":"Optom Vis Sci"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ajo.2006.10.054","article-title":"Peripapillary schisis in glaucoma patients with narrow angles and increased intraocular pressure","volume":"143","author":"Kahook","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1001\/archopht.123.2.270","article-title":"Macular schisis detachment associated with angle-closure glaucoma","volume":"123","author":"Hollander","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4274\/tjo.68815","article-title":"Three-dimensional optical coherence tomography imaging and treatment of glaucomatousoptic nerve head defects associated with schisis-like maculopathy","volume":"47","author":"\u00d6ztas","year":"2017","journal-title":"Turk J Ophthalmol"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/ICB.0000000000000652","article-title":"Paracentral acute middle maculopathy in primary congenital glaucoma","volume":"14","author":"Aribas","year":"2020","journal-title":"Retin Cases Brief Rep"},{"key":"B6-20240828","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4103\/meajo.MEAJO_79_17","article-title":"Occult optic disc pit maculopathy in a glaucomatous disc","volume":"24","author":"Nagesha","year":"2017","journal-title":"Middle East Afr J Ophthalmol"},{"key":"B7-20240828","doi-asserted-by":"crossref","first-page":"1536030","DOI":"10.1155\/2017\/1536030","article-title":"Transient peripapillary retinoschisis in glaucomatous eyes","volume":"2017","author":"Van der Schoot","year":"2017","journal-title":"J Ophthalmol"},{"key":"B8-20240828","doi-asserted-by":"crossref","first-page":"356","DOI":"10.5935\/0034-7280.20180078","article-title":"Peripapillary retinoschisis and serous detachment of neurosensory retina after a non-penetrating deep sclerectomy","volume":"77","author":"Pedruzzi","year":"2018","journal-title":"Rev Bras Oftalmol"},{"key":"B9-20240828","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0161-6420(80)35278-0","article-title":"Congenital pits of the optic nerve head. 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