{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:57:31Z","timestamp":1790366251227,"version":"4.1.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Adenoviral conjunctivitis may lead to subepithelial corneal infiltrates as a late complication. Herein, we aim to present a 19-year-old healthy female, who developed bilateral disciform keratitis three weeks after suffering adenoviral conjunctivitis. She presented with widespread subepithelial corneal infiltrates in addition to central corneal edema with white distinct border resembling immune stromal ring, as well as Descemet's folds and keratic precipitates in the central area. Following topical corticosteroid and ganciclovir for 10 days, her condition improved. After 1 month, she had another episode. Short-term topical corticosteroids in addition to long-term topical cyclosporine and nonpreserved artificial tears were able to prevent further recurrences.<\/jats:p>","DOI":"10.4103\/ijo.ijo_688_17","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T09:45:03Z","timestamp":1514454303000},"page":"132-134","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Bilateral disciform keratitis of presumed adenoviral etiology"],"prefix":"10.4103","volume":"66","author":[{"given":"Rana","family":"Altan-Yaycioglu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Adana Teaching and Medical Research Center, School of Medicine, Baskent University, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Poyraz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cukurova Dr. Askim Tufekci State Hospital, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251013","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/ICU.0b013e3283477cb5","article-title":"Adenovirus advances: New diagnostic and therapeutic options","volume":"22","author":"Kaufman","year":"2011","journal-title":"Curr Opin Ophthalmol"},{"key":"R2-20251013","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.survophthal.2015.04.001","article-title":"Adenoviral keratoconjunctivitis","volume":"60","author":"Jhanji","year":"2015","journal-title":"Surv Ophthalmol"},{"key":"R3-20251013","first-page":"475","article-title":"Epidemic keratoconjunctivitis: The current situation and recommendations for prevention and treatment","volume":"108","author":"Meyer-R\u00fcsenberg","year":"2011","journal-title":"Dtsch Arztebl Int"},{"key":"R4-20251013","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/00003226-199409000-00011","article-title":"Activity of ganciclovir against human adenovirus type-5 infection in cell culture and cotton rat eyes","volume":"13","author":"Trousdale","year":"1994","journal-title":"Cornea"},{"key":"R5-20251013","first-page":"315","article-title":"Antiadenoviral effects of ganciclovir in types inducing keratoconjunctivitis by quantitative polymerase chain reaction methods","volume":"8","author":"Huang","year":"2014","journal-title":"Clin Ophthalmol"},{"key":"R6-20251013","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/ceo.12076","article-title":"Adenoviral keratoconjunctivitis associated with stromal oedema and keratic precipitates","volume":"41","author":"Tsagkataki","year":"2013","journal-title":"Clin Exp Ophthalmol"},{"key":"R7-20251013","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0161-6420(02)01772-4","article-title":"Bilateral herpetic keratoconjunctivitis","volume":"110","author":"Souza","year":"2003","journal-title":"Ophthalmology"},{"key":"R8-20251013","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/bjophthalmol-2013-304625","article-title":"Clinical features and management of cytomegalovirus corneal endotheliitis: Analysis of 106 cases from the Japan corneal endotheliitis study","volume":"99","author":"Koizumi","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"R9-20251013","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1001\/archopht.1970.00990040038010","article-title":"Corneal infiltrates in epidemic keratoconjunctivitis. Response to double-blind corticosteroid therapy","volume":"84","author":"Laibson","year":"1970","journal-title":"Arch Ophthalmol"},{"key":"R10-20251013","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/eye.2017.4","article-title":"Comparison of clinical outcome with different treatment regimens in acute adenoviral keratoconjunctivitis","volume":"31","author":"Asena","year":"2017","journal-title":"Eye (Lond)"},{"key":"R11-20251013","doi-asserted-by":"crossref","first-page":"49","DOI":"10.17116\/oftalma2015131449-55","article-title":"Clinical and immunological comparisons of therapeutic regimens for corneal infiltrates secondary to adenoviral keratoconjunctivitis","volume":"131","author":"Maychuk","year":"2015","journal-title":"Vestn Oftalmol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223307-201866010-00029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:30:52Z","timestamp":1787758252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223307-201866010-00029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_688_17","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-08-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}