{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:33:46Z","timestamp":1787772826454,"version":"build-2784847793"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2]]},"abstract":"\n Purpose:<\/jats:title>\n The objective of this study was to identify the diagnostic features of optic nerve head melanocytoma (ONH-MCT) on spectral domain optical coherence tomography (SD OCT) and OCT angiography (OCT-A).<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Retrospective study of 11 patients for their demographic, clinical features and imaging including SD OCT (tumour location, extent and interface) and OCT-A (surface and intrinsic vascularity) were reviewed. Flow rate percentage (FR %) was calculated over the lesion and compared to fellow eye and similar pigmented lesions.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The average age was 52.8 \u00b1 10.9 years. ONH-MCT tumors occupied 3-tissue spaces- optic disc (n = 2), retinal layer (n = 5) and retina-choroidal layers (n = 4). SD OCT (11 eyes) showed elevated hyper reflective disorganized retinal layers with posterior shadowing (9 eyes) and hyper reflective dots within the tumor (all eyes). Microvascular features on OCT-A (8 eyes) in radial peripapillary capillary slab showed surface vascularization (7 eyes) and intrinsic vascularity in choroidal slab (8 eyes) with surrounding hypo reflective boundary. The mean FR % was higher at 65.1 \u00b1 3.77% (CI: 61.9-68.2) compared to mean FR at 60.4 \u00b1 1.06% (CI: 59.5-61.2) in the fellow eye (p = 0.01). Comparison with nevus and melanoma SD OCT showed a high reflective choroidal layer with normal or irregular outer retinal layers respectively; OCT-A showed hypo reflective area at the center with hyper reflective boundary and iso reflective area at center with hyper reflective boundary respectively.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n SD OCT and OCT-A features may help to differentiate ONH-MCT from clinically similar looking pigmented lesions like nevus and melanoma.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_710_20","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:20:11Z","timestamp":1611015611000},"page":"332-336","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Optic nerve head melanocytoma"],"prefix":"10.4103","volume":"69","author":[{"given":"Vishal","family":"Raval","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swathi","family":"Kaliki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taraprasad","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun D","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-29-20240828","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/00004397-196206000-00010","article-title":"Melanocytoma of the optic disk","volume":"2","author":"Zimmerman","year":"1962","journal-title":"Int Ophthalmol Clin"},{"key":"R2-29-20240828","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.survophthal.2005.12.011","article-title":"Melanocytoma of the optic disk: A review","volume":"51","author":"Shields","year":"2006","journal-title":"Surv Ophthalmol"},{"key":"R3-29-20240828","first-page":"1739","article-title":"Melanocytoma of the optic disc in 115 cases.The 2004 Samuel Johnson Memorial Lecture, part 1","volume":"111","author":"Shields","year":"2004","journal-title":"Ophthalmology"},{"key":"R4-29-20240828","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3109\/08820538.2015.1046558","article-title":"Malignant transformation of optic nerve melanocytoma into melanoma associated with ocular ischemic syndrome and oculo-cardiac reflex: Case report and review of the literature","volume":"32","author":"Salinas-La Rosa","year":"2017","journal-title":"Semin 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tumors?","volume":"2017","author":"Toledo","year":"2017","journal-title":"J Ophthalmol"},{"key":"R9-29-20240828","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2147\/OPTH.S148897","article-title":"Optical coherence tomography angiography in choroidal melanoma and nevus","volume":"12","author":"Ghassemi","year":"2018","journal-title":"Clin Ophthalmol"},{"key":"R10-29-20240828","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4103\/0301-4738.154377","article-title":"Review of spectral domain enhanced depth imaging optical coherence tomography of tumors of the choroid","volume":"63","author":"Shields","year":"2015","journal-title":"Indian J Ophthalmol"},{"key":"R11-29-20240828","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3928\/23258160-20170329-14","article-title":"Optical coherence tomography angiography features in melanocytoma of the optic nerve","volume":"48","author":"Carnevali","year":"2017","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"R12-29-20240828","doi-asserted-by":"crossref","first-page":"e239","DOI":"10.1016\/j.jcjo.2018.01.038","article-title":"Swept source optical coherence tomography angiography in optic disc melanocytoma","volume":"53","author":"Jain","year":"2018","journal-title":"Canadian J Ophthal"},{"key":"R13-29-20240828","doi-asserted-by":"crossref","first-page":"7876","DOI":"10.3390\/ijms16047876","article-title":"The changes of angiogenesis and immune cell infiltration in the intra- and peri-tumoral melanoma microenvironment","volume":"16","author":"Zidlik","year":"2015","journal-title":"Int J Mol Sci"}],"container-title":["Indian Journal of 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