{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:42:16Z","timestamp":1793122936808,"version":"4.5.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Evaluation of combined corneal tomographic and biomechanical parameters in subclinical\/forme fruste keratoconus (ScKC\/FFKC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Cross-sectional observational case-control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods: Inclusion Criteria:<\/jats:title>\n                    <jats:p>Thirty-one eyes with ScKC (fellow eye of KC with any one sign: keratometry &gt;47 diopters, cylinder &gt;1.5 D, central corneal thickness &lt;500 \u00b5m, with\/without abnormal topography) or FFKC (fellow eye of KC with normal topography and slit lamp examination) &gt;13 years (cases) and 44 eyes of age-matched 22 healthy subjects (controls).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Exclusion Criteria:<\/jats:title>\n                    <jats:p>Clinically diagnosed KC, presence of corneal scars, and prior ocular surgery eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Parameters:<\/jats:title>\n                    <jats:p>\n                      Sixteen Pentacam, 15 Corvis ST, and five Sirius parameters were analyzed using paired sample\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test, and a subsample found to be significantly different was used in receiver operating characteristic curve analysis. The Youden index was calculated, and Pearson\u2019s correlation analysis was done.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Five Pentacam, three Corvis ST, and two Sirius parameters had an area under curve (AUC) &gt;0.75. Tomographic and biomechanical index (TBI) (cutoff 0.59, 95% specificity, 77% sensitivity), Belin Ambrosio enhanced ecstasia display (cutoff 1.8, 81% specificity, 80% sensitivity), and symmetry index of posterior corneal curvature (cutoff 0.16, 97% specificity, 67% sensitivity) best identified early KC. TBI strongly correlated with maximum Pentacam parameters in both cases and controls. Corvis biomechanical index strongly correlated only in cases, and SP-A1-SD weakly correlated in cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Upon combined analysis, the average sensitivity and specificity, respectively, of top three parameters (according to AUC) from Pentacam and Corvis ST were 74.1% and 95.4% for posterior elevation and TBI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>The trial was registered in Clinical Trial Registry of India on January 28, 2022. The Trial Registration Number is REF\/2022\/01\/050638.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_766_24","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T12:09:47Z","timestamp":1720699787000},"page":"1337-1345","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Combined corneal biomechanical and tomographical indices in subclinical and forme fruste keratoconus"],"prefix":"10.4103","volume":"72","author":[{"given":"Meghna","family":"Ganesh","sequence":"first","affiliation":[{"name":"Guru Nanak Eye Centre, Maharaja Ranjeet Singh Marg, LNJP Colony, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Arora","sequence":"additional","affiliation":[{"name":"Guru Nanak Eye Centre, Maharaja Ranjeet Singh Marg, LNJP Colony, New Delhi, Delhi, 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