{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:02Z","timestamp":1786650002355,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate the pathogenesis of type-2 macular telangiectasia (MacTel) by comparing the levels of glial fibrillary acidic protein (GFAP), aquaporin-4 (AQP4), and K+ inwardly rectifying channel 4.1 (Kir4.1) in the aqueous humor of diagnosed patients and individuals who had no ophthalmological disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective study included nine patients with cataract and MacTel type 2 (group 1) and patients without any ophthalmological pathology other than senile cataract (group 2). We comparatively analyzed the groups\u2019 GFAP, AQP4, and Kir4.1 levels in the anterior chamber fluid, which was sampled intraoperatively during the cataract surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The GFAP levels were found to be 601.18 \u00b1 66.19 pg\/mL in the patient group and 1059 \u00b1 537 pg\/mL in the control group, and the difference was statistically significant. (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.019) The mean AQP4 levels were lower (1.5 \u00b1 1.02 ng\/mL) in the patient group than in the control group (2.81 \u00b1 1.19 pg\/mL) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.012). There was no significant difference in terms of the mean Kir4.1 levels between the groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.453). There was a significant negative correlation between the postoperative best corrected visual acuity (logMAR) and GFAP and AQP4 (for GFAP; r = -0.473\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02, for AQP4 r = -0.463\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.023).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>GFAP and AQP4 levels may be related to glial cell dysfunction and disturbances in retinal fluid balance in the pathophysiology of MacTel type 2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_784_25","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T13:00:25Z","timestamp":1769346025000},"page":"274-278","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["M\u00fcller cell markers in aqueous humor of patients with type-2 macular telangiectasia"],"prefix":"10.4103","volume":"74","author":[{"given":"El\u00e7in","family":"Osmanl\u0131","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Mugla Sitki Kocman University, Mu\u011fla, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabahattin","family":"S\u00fcl","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Mugla Sitki Kocman University, Mu\u011fla, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Kaderli","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Mugla Sitki Kocman University, Mu\u011fla, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema Tamer","family":"Kaderli","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Mugla Sitki Kocman University, Mu\u011fla, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dcmm\u00fchani","family":"T\u00fcrk\u00e7\u00fc","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Department, Mugla Sitki Kocman University, Mu\u011fla, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/S0161-6420(93)31447-8","article-title":"Idiopathic juxtafoveolar retinal telangiectasis. 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