{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:22:40Z","timestamp":1787764960738,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the factors affecting corneal deformation amplitude (DA) measured using Corvis ST in eyes with open-angle glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective, longitudinal study included 48 eyes with open-angle glaucoma who required additional intraocular pressure (IOP)-lowering drops. All eyes underwent a complete eye examination at baseline, including a Corvis ST, which was repeated 4\u20138 weeks after the change in therapy. Factors affecting the corneal biomechanics, namely the DA, were determined using mixed effect models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age of the cohort was 65.0 \u00b1 7.9 years. The mean IOP reduced from 23.4 \u00b1 5.4 mmHg to 17.9 \u00b1 5 mmHg after the change in glaucoma treatment (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The DA increased from 0.89 \u00b1 0.16 mm to 1.00 \u00b1 0.13 mm after IOP reduction (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). On mixed effect model analysis, IOP (\u22120.02 \u00b1 0.001,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and corneal pachymetry (\u22120.0003 \u00b1 0.0001,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02) affected the change in the DA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>IOP and corneal pachymetry affect the DA and must be accounted for when using Corvis ST to evaluate corneal biomechanics in glaucoma.<\/jats:p>\n                  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