{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:49:21Z","timestamp":1790948961747,"version":"4.1.0"},"reference-count":56,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To study the antifungal susceptibility of common corneal pathogenic fungi to antifungal agents in the North Indian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Prospective study of the antifungal sensitivity testing (natamycin, amphotericin B, voriconazole, itraconazole, fluconazole, posaconazole, caspofungin, micafungin) of fungal isolates from 50 cases of culture positive fungal keratitis by using E test method. Details noted included demographic data, visual acuity, clinical details, grade of keratitis, healing time, and success in medical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 50 patients with fungal keratitis (mean age: 40.28 \u00b1 16.77 years), 12 eyes healed within 3 weeks, 14 had a delayed healing response, and 24 had chronic keratitis. Among the 15 cases of Fusarium isolates, 93.3% were sensitive to natamycin, while 40% to amphotericin B; 66.6% to voriconazole, 13.4% to itraconazole and fluconazole each. 80% of Fusarium cases (n = 12) showed susceptibility to posaconazole. Among Aspergillus flavus isolates, 53.4% (n = 8) were sensitive to natamycin, with only 40% (n = 7) showing sensitivity to amphotericin B and good susceptibility to azoles. MIC against susceptible Fusarium spp. for natamycin was 3\u201316 \u00b5g\/mL, amphotericin B: 1\u20138 \u00b5g\/mL, voriconazole: 0.5\u20131.5 \u00b5g\/mL, itraconazole: 0.5\u201312 \u00b5g\/mL, posaconazole: 0.094\u20131.5 \u00b5g\/mL. MIC against Aspergillus flavus was natamycin: 8\u201332 \u00b5g\/mL, amphotericin B: 0.5\u201316 \u00b5g\/mL, voriconazole: 0.025\u20134 \u00b5g\/mL, itraconazole: 0.125\u20138 \u00b5g\/mL, posaconazole: 0.047\u20130.25 \u00b5g\/mL; against Aspergillus niger isolates, to natamycin was 6 \u00b5g\/mL (n=1), amphotericin B 8\u201312 \u00b5g\/mL (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 3), voriconazole: 0.125\u20130.19 \u00b5g\/mL (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 3), itraconazole: 0.38\u20130.75 \u00b5g\/mL, posaconazole: 0.064\u20130.19 \u00b5g\/mL and against Aspergillus fumigatus (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1), was natamycin4 \u00b5g\/mL, amphotericin B - 8 \u00b5g\/mL, voriconazole 0.25 \u00b5g\/mL, itraconazole 1 \u00b5g\/mL, and posaconazole 0.19 \u00b5g\/mL. MIC against susceptible Acremonium spp. for natamycin was 1.5\u201316 \u00b5g\/mL, amphotericin B: 0.5\u20138 \u00b5g\/mL, voriconazole: 0.19\u20133 \u00b5g\/mL, itraconazole: 0.125 \u00b5g\/mL, posaconazole: 0.125\u20130.5 \u00b5g\/mL and against susceptible Curvularia was natamycin 0.75\u20134 \u00b5g\/mL, amphotericin B 0.5\u20131 \u00b5g\/mL, voriconazole 0.125\u20130.19 \u00b5g\/mL, itraconazole 0.047\u20130.094 \u00b5g\/mL, posaconazole 0.047\u20130.094 \u00b5g\/mL. MIC against Mucor spp.+ Rhizopus spp. (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1) was natamycin: 8 \u00b5g\/mL, amphotericin B: 0.75 \u00b5g\/mL, posaconazole: 1.5 \u00b5g\/mL. MIC against of Alternaria (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1) was voriconazole: 0.19 \u00b5g\/mL, posaconazole: 0.094 \u00b5g\/mL. MIC against Penicillium (n=1) was natamycin: 8 \u00b5g\/mL, voriconazole: 0.25 \u00b5g\/mL, itraconazole: 0.5 \u00b5g\/mL, and Posaconazole: 0.125 \u00b5g\/mL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our observations highlight the variations in susceptibility to antifungal agents. Posaconazole seems to be effective with low MIC against common corneal pathogenic fungal isolates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_855_22","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T08:53:31Z","timestamp":1670316811000},"page":"4270-4283","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of antifungal susceptibility and clinical characteristics in fungal keratitis in a tertiary care center in North India"],"prefix":"10.4103","volume":"70","author":[{"given":"Murugesan","family":"Vanathi","sequence":"first","affiliation":[{"name":"Cornea, Lens and Refractive Surgery Services, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Naik","sequence":"additional","affiliation":[{"name":"Cornea, Lens and Refractive Surgery Services, All India 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