{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:39Z","timestamp":1786649739287,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To study the relationship between intraocular pressure (IOP) and mean ocular perfusion pressure (MOPP) in patients with POAG and NTG. The secondary objective was to identify other contributory ischemic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was an observational cross-sectional study from a tertiary eye hospital in patients who underwent full-day diurnal variation of tension (DVT). Blood pressure (BP) and IOP measurements were done every 3 h over 24 h. Mean arterial pressure (MAP) and MOPP were calculated. The nocturnal dip in BP was assessed; patients were classified as non-dippers, dippers, and over-dippers. The circadian MOPP fluctuation (CMF) was calculated using the Kruskal\u2013Wallis test, and its relationship with type and severity of visual field was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 149 patients were evaluated; 109 were classified as NTG, and 40 were classified as POAG. A nocturnal dip in BP was noted in 20% of NTG and 17.5% of POAG. The MAP was found to be lower in patients with NTG than POAG. In the NTG subgroup, we found that 20% of patients were over-dippers, 32% were dippers, and 48% were non-dippers. The CMF showed a greater fluctuation for over-dippers (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004 for the RE and 0.003 for the LE) than dippers and non-dippers. A weak positive correlation of CMF with the severity of fields was found.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A 24-h monitoring of IOP, BP, MOPP, and assessment of systemic risk factors for primary glaucoma acts as an invaluable tool for the comprehensive management of NTG despite the limitations posed by DVT and BP recording.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_861_21","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T07:51:02Z","timestamp":1644997862000},"page":"569-573","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Significance of non-intraocular pressure (IOP)-related factors particularly in normal tension glaucoma: Looking beyond IOP"],"prefix":"10.4103","volume":"70","author":[{"given":"Shoruba","family":"Dinakaran","sequence":"first","affiliation":[{"name":"Glaucoma Service, Narayana Nethralaya-2, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parin","family":"Mehta","sequence":"additional","affiliation":[{"name":"Glaucoma Service, Narayana Nethralaya-2, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Mehta","sequence":"additional","affiliation":[{"name":"Glaucoma Service, Narayana Nethralaya-2, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavin","family":"Tilva","sequence":"additional","affiliation":[{"name":"Glaucoma Service, Narayana Nethralaya-2, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devanshu","family":"Arora","sequence":"additional","affiliation":[{"name":"Glaucoma Service, Narayana Nethralaya-2, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Tejwani","sequence":"additional","affiliation":[{"name":"Glaucoma Service, Narayana Nethralaya-2, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1001\/archopht.1960.01840010496004","article-title":"The significance of the diurnal tension variations in normal and glaucomatous eyes","volume":"64","author":"Drance","year":"1960","journal-title":"Arch Ophthalmol"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ophtha.2006.07.060","article-title":"Fluctuation of intraocular pressure and glaucoma progression in the early manifest glaucoma trial","volume":"114","author":"Bengtsson","year":"2007","journal-title":"Ophthalmology"},{"key":"R3-20251006","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.ophtha.2007.10.031","article-title":"Intraocular pressure fluctuation a risk factor for visual field progression at low intraocular pressures in the advanced glaucoma intervention study","volume":"115","author":"Caprioli","year":"2008","journal-title":"Ophthalmology"},{"key":"R4-20251006","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00061198-200004000-00002","article-title":"Large diurnal fluctuations in intraocular pressure are an independent risk factor in patients with glaucoma","volume":"9","author":"Asrani","year":"2000","journal-title":"J Glaucoma"},{"key":"R5-20251006","doi-asserted-by":"crossref","first-page":"141905","DOI":"10.1155\/2015\/141905","article-title":"Systemic and ocular hemodynamic risk factors in glaucoma","volume":"2015","author":"Choi","year":"2015","journal-title":"Biomed Res Int"},{"key":"R6-20251006","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0002-9394(88)90118-3","article-title":"Response of blood flow to warm and cold in normal and low-tension glaucoma patients","volume":"105","author":"Drance","year":"1988","journal-title":"Am J Ophthalmol"},{"key":"R7-20251006","first-page":"1105","article-title":"Migraine and low-tension glaucoma. 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