{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:23:13Z","timestamp":1787840593859,"version":"build-2784847793"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>A comprehensive understanding of the ocular presentations of systemic lymphoma (SL) is needed for early recognition and treatment to improve outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The ocular manifestations of 17 patients with SL were retrospectively summarized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 17 SL patients, 12 (21 eyes) presented with secondary vitreoretinal lymphoma (SVRL) and five (8 eyes) presented with viral retinitis. Among those with SVRL, 16 eyes (76.2%) exhibited only vitreoretinal involvement, three eyes (14.3%) had both choroid and vitreoretinal involvement, and two eyes (9.5%) showed lacrimal gland and vitreoretinal involvement. Ocular symptoms occurred at a median interval of 63 months (range: 4\u2013220 months) after SL diagnosis. Ocular manifestations included keratic precipitates in 10 eyes (47.6%), anterior chamber cells in 10 eyes (47.6%), vitreous cells in 18 eyes (85.7%), subretinal infiltrates in six eyes (28.6%), optic nerve involvement in three eyes (14.3%), neovascular glaucoma in five eyes (23.8%), and ciliary body\/choroidal involvement in three eyes (14.3%). Patients received intravitreal methotrexate injections and systemic chemotherapy. The 3-year survival rate was 47.5%. Viral retinitis manifested as vitritis, peripheral retinal focal necrosis, and retinal vasculitis, and among those five patients, the median interval from SL diagnosis to ocular involvement was 15 months (range: 9\u201328 months). These patients received antiviral therapy and intravitreal ganciclovir injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>SVRL and viral retinitis are two ocular manifestations of SL. Vitreous biopsy and PCR testing are valuable for distinguishing between them. Our findings support the importance of long-term ocular surveillance in patients with SL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_883_25","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T19:00:20Z","timestamp":1758308420000},"page":"1607-1612","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Ocular manifestations of systemic lymphoma"],"prefix":"10.4103","volume":"73","author":[{"given":"Tingting","family":"Jiang","sequence":"first","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, 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