{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:55Z","timestamp":1786649755911,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare the retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer thickness, central subfield thickness (CSFT), and parafoveal and perifoveal thickness in children of different age groups with young adult controls by using spectral-domain optical coherence tomography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This cross-sectional study included children aged 6\u201317 years and adult controls (18\u201322 years) \u2013 group 1: 6\u20139 years (57 eyes), group 2: 10\u201313 years (116 eyes), group 3: 14\u201317 years (66 eyes), and group 4 (controls): 18\u201322 years (61 eyes). A mixed-effects model was used to compare the OCT parameters among the groups, along with multivariable analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Analysis of 300 eyes of 152 patients was done. Group 2 (99.7 \u00b1 1.1 \u00b5m,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03) and group 3 (100.4 \u00b1 1.5 \u00b5m,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03) had thicker RNFL on average as compared to group 4 (95.6 \u00b1 1.6 \u00b5m) on multivariable analysis. In pairwise comparison, group 2 (129.8 \u00b1 2.5 \u00b5m,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02) and group 3 (132.6 \u00b1 2.4 \u00b5m,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004) had thicker inferior RNFL compared to adult controls (122.4 \u00b1 2.5 \u00b5m); superior RNFL was thicker in group 2 (129.6 \u00b1 2.0 \u00b5m,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01) and group 3 (131.2 \u00b1 2.6 \u00b5m,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.008) compared to group 1 (120.9 \u00b1 2.8 \u00b5m). On multivariable analysis, adult controls had thicker CSFT (236.5 \u00b1 2.6 \u00b5m) than group 1 (222.7 \u00b1 3.1 \u00b5m) and group 2 (229.6 \u00b1 2.3 \u00b5m). Similarly, on pairwise comparison, adult controls had thicker parafoveal superior quadrants (320.5 \u00b1 2.5 \u00b5m) and inferior quadrants (317.5 \u00b1 2.3 \u00b5m) when compared with groups 1 and 2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>RNFL thickness seems to increase up to 17 years and then starts reducing, unlike CSFT, which increases with age from 6 to 22 years. A differential growth occurs in the different quadrants of RNFL and macula with age with some quadrants increasing in thickness as compared to the others.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_889_24","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T10:00:24Z","timestamp":1735293624000},"page":"731-736","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of peripapillary and macular Optical Coherence Tomography parameters between children and young adults"],"prefix":"10.4103","volume":"73","author":[{"given":"Gazella B","family":"Warjri","sequence":"first","affiliation":[{"name":"VST Centre for Glaucoma Care, L V Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsha L","family":"Rao","sequence":"additional","affiliation":[{"name":"Narayana Nethralaya, Bannerghatta Road, Hulimavu, Bangalore, Karnataka, India"},{"name":"University Eye Clinic Maastricht, University Medical Center, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virender","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Child Sight Institute, Nimmagadda Prasad Children\u2019s Eye Care Centre, L V Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirisha","family":"Senthil","sequence":"additional","affiliation":[{"name":"VST Centre for Glaucoma Care, L V Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"issue":"Suppl 1","key":"R1-20260422","first-page":"S53","article-title":"The role of standard automated perimetry and newer functional methods for glaucoma diagnosis 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