{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:25:02Z","timestamp":1787840702778,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the clinical features, radiologic, and histopathologic characteristics of patients with orbital rhabdomyosarcoma (RMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The records of 14 patients with histologically proven orbital rhabdomyosarcoma between November 2012 and January 2024 were evaluated retrospectively. The age, gender, referring diagnosis, year of diagnosis, clinical features, histopathological results, radiology reports, follow-up period, management plans, and prognosis were obtained from patient electronic files and descriptively presented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 14 patients with a mean age of 12.64 \u00b1 6.68 years were evaluated. Ten were males 71.43%, and four were females 28.57%. Six (42.85%) patients presented initially with proptosis as the main presenting complaint, and all of the patients had some degree of proptosis. Eleven patients (78.57%) had embryonal RMS, and three patients (21.42%) had alveolar RMS subtypes. The follow-up period ranged between 6 months and 6 years (26.36 \u00b1 21.55 months). In 10 (71.42%) patients, there was a good response to treatment with no orbital recurrence or progression of the lesion during the follow-up period. Two patients had (14.28%) mortality during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Rhabdomyosarcoma management and diagnosis are important for preventing its spread and threatening patients\u2019 life and visual survival. Orbital RMS is a rare but important diagnosis in the orbit, and differential diagnoses need to be considered because RMS may have presenting features resembling other inflammatory orbital conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_921_24","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T15:00:15Z","timestamp":1753714815000},"page":"1132-1137","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Orbital Rhabdomyosarcoma: Clinicodemographic Features and Outcomes from Turkey"],"prefix":"10.4103","volume":"73","author":[{"given":"Burak","family":"Ulas","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Cukurova University Faculty of Medicine, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Altan Atakan","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Cukurova University Faculty of Medicine, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadi","family":"Aljundi","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Cukurova University Faculty of Medicine, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"R1-20260421","doi-asserted-by":"crossref","first-page":"202","DOI":"10.18502\/jovr.v18i2.13187","article-title":"A survey on orbital space-occupying lesions during a twelve-year period from a referral center in Iran","volume":"18","author":"Bagheri","year":"2023","journal-title":"J Ophthalmic Vis Res"},{"key":"R2-20260421","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/his.14449","article-title":"Evolving classification of rhabdomyosarcoma","volume":"80","author":"Agaram","year":"2022","journal-title":"Histopathology"},{"key":"R3-20260421","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1097\/MS9.0000000000000501","article-title":"A rare case of pediatric orbital rhabdomyosarcoma in Nepal: A case report","volume":"85","author":"Shrestha","year":"2023","journal-title":"Ann Med Surg"},{"key":"R4-20260421","first-page":"26","article-title":"Orbital rhabdomyosarcoma: Review","volume":"3","author":"Korkmaz","year":"2022","journal-title":"Eur Eye Res"},{"key":"R5-20260421","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.wneu.2024.07.110","article-title":"Orbital rhabdomyosarcoma: Comprehensive review of epidemiology, clinical staging, and treatment outcomes","volume":"190","author":"Al-Shalchy","year":"2024","journal-title":"World Neurosurg"},{"key":"R6-20260421","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1177\/107327480401100507","article-title":"Orbital rhabdomyosarcoma","volume":"11","author":"Karcioglu","year":"2004","journal-title":"Cancer Control"},{"key":"R7-20260421","doi-asserted-by":"crossref","first-page":"610","DOI":"10.4103\/IJO.IJO_2716_23","article-title":"Clinicodemographic profile of orbital exenteration in a tertiary eye care center-A 20-year experience","volume":"72","author":"Meel","year":"2024","journal-title":"Indian J Ophthalmol"},{"key":"R8-20260421","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.ophtha.2003.01.002","article-title":"Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1","volume":"111","author":"Shields","year":"2004","journal-title":"Ophthalmology"},{"key":"R9-20260421","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.3389\/fonc.2020.01590","article-title":"Score for the survival probability of patients with orbital rhabdomyosarcoma after surgery: A long-term and large cohort study","volume":"10","author":"Zhang","year":"2020","journal-title":"Front Oncol"},{"key":"R10-20260421","doi-asserted-by":"crossref","first-page":"101475","DOI":"10.1016\/j.epsc.2020.101475","article-title":"Pediatric primary orbital rhabdomyosarcoma","volume":"59","author":"Thien","year":"2020","journal-title":"J Pediatr Surg Case Rep"},{"key":"R11-20260421","first-page":"108","article-title":"Orbital rhabdomyosarcoma in the pediatric population: A prospective, observational study from Mid-West Nepal","volume":"37","author":"Bastola","year":"2022","journal-title":"Acad J Health Sci"},{"key":"R12-20260421","first-page":"e188","article-title":"Clinicopathological analysis of head and neck rhabdomyosarcoma: A series of 10 cases and literature review","volume":"23","author":"Pontes","year":"2018","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"R13-20260421","doi-asserted-by":"crossref","first-page":"110403","DOI":"10.1016\/j.ijporl.2020.110403","article-title":"Pediatric head and neck rhabdomyosarcoma: An analysis of treatment and survival in the United States (1975\u20132016)","volume":"139","author":"Darwish","year":"2020","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"R14-20260421","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4103\/0019-509X.38941","article-title":"Orbital rhabdomyosarcoma: A case series","volume":"44","author":"Kaliaperumal","year":"2007","journal-title":"Indian J Cancer"},{"key":"R15-20260421","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1055\/s-0040-1722635","article-title":"Primary malignant orbital tumors","volume":"82","author":"Laplant","year":"2021","journal-title":"J Neurol Surg B Skull Base"},{"key":"R16-20260421","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.sjopt.2013.06.004","article-title":"Orbital rhabdomyosarcomas: A review","volume":"27","author":"Jurdy","year":"2013","journal-title":"Saudi J Ophthalmol"},{"key":"R17-20260421","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1200\/JCO.2001.19.1.197","article-title":"Treatment of orbital rhabdomyosarcoma: Survival and late effects of treatment\u2014Results of an International Workshop","volume":"19","author":"Oberlin","year":"2001","journal-title":"Am Soc Clin Oncol"},{"key":"R18-20260421","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.3332\/ecancer.2023.1539","article-title":"Outcome and prognostic variables in childhood rhabdomyosarcoma (RMS) with emphasis on impact of FOXO1 fusions in non-metastatic RMS: Experience from a tertiary cancer centre in India","volume":"17","author":"Ramanathan","year":"2023","journal-title":"Ecancermedicalscience"},{"key":"R19-20260421","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.oftal.2020.09.004","article-title":"Multidisciplinary approach to orbital embryonic rhabdomyosarcoma: About a case","volume":"96","author":"D\u00e1vila-Camargo","year":"2021","journal-title":"Arch Soc Esp Oftalmol"},{"key":"R20-20260421","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1200\/JCO.2005.05.3801","article-title":"Analysis of prognostic factors in patients with nonmetastatic rhabdomyosarcoma treated on intergroup rhabdomyosarcoma studies III and IV: The children\u2019s oncology group","volume":"24","author":"Meza","year":"2006","journal-title":"J Clin Oncol"},{"key":"R21-20260421","doi-asserted-by":"crossref","first-page":"101274","DOI":"10.1016\/j.ajoc.2022.101274","article-title":"Persistent mass after treatment for orbital rhabdomyosarcoma","volume":"20","author":"Siktberg","year":"2022","journal-title":"Am J Ophthalmol Case Rep"},{"key":"R22-20260421","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/ceo.12370","article-title":"Long-term evaluation of orbital rhabdomyosarcoma in children","volume":"43","author":"Boutroux","year":"2015","journal-title":"Clin Exp Ophthalmol"},{"key":"R23-20260421","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/aos.14596","article-title":"Second-line therapy in young patients with relapsed or refractory orbital rhabdomyosarcoma","volume":"99","author":"Zloto","year":"2021","journal-title":"Acta Ophthalmol"},{"key":"R24-20260421","doi-asserted-by":"crossref","first-page":"e29644","DOI":"10.1002\/pbc.29644","article-title":"Clinical group and modified TNM stage for rhabdomyosarcoma: A review from the Children\u2019s Oncology Group","volume":"69","author":"Crane","year":"2022","journal-title":"Pediatr Blood Cancer"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_921_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:27:25Z","timestamp":1787837245000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_921_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_921_24","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]},"assertion":[{"value":"2024-04-18","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}