{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:32:11Z","timestamp":1787772731024,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Obtaining a better understanding of the pathogenesis of primary angle-closure disease (PACD) still requires studies that provide measurements of anterior and posterior biometric characteristics together and that assess the relationship between them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In total, 201 eyes were enrolled in this cross-sectional study: 50 normal controls, 49 primary angle-closure suspect (PACS), 38 primary angle closure (PAC), and 64 primary angle-closure glaucoma (PACG) eyes. The anterior and posterior structural features were measured by anterior segment optical coherence tomography and swept-source optical coherence tomography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All PACD groups had smaller anterior chamber depth (ACD), anterior chamber area (ACA), anterior chamber volume (ACV), angle opening distance at 750 \u03bcm from the scleral spur (AOD750), trabecular\u2013iris space area at 750 \u03bcm from the scleral spur (TISA750), and angle recess area (ARA), as well as a larger lens vault (LV), than controls (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The PACS and PAC groups had thicker iris thickness at 750 \u03bcm from the scleral spur (IT750) than controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.017 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002, respectively). Choroidal thickness (CT) was not statistically different among normal, PACS, PAC, and PACG eyes. Univariate and multivariate linear regression analysis revealed a significant association between thinner IT750 and increased CT in PACD eyes (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.031, univariate analysis;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.008, multivariate analysis).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Thinner iris thickness was associated with increased CT in PACD eyes; however, the underlying mechanism needs further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_936_20","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T05:15:35Z","timestamp":1615958135000},"page":"865-870","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["The anterior and posterior biometric characteristics in primary angle-closure disease"],"prefix":"10.4103","volume":"69","author":[{"given":"Wenbin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20240828","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"R2-18-20240828","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1136\/bjo.85.11.1277","article-title":"Glaucoma in China: How big is the problem?","volume":"85","author":"Foster","year":"2001","journal-title":"Br J Ophthalmol"},{"key":"R3-18-20240828","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1136\/bjo.86.2.238","article-title":"The definition and classification of glaucoma in prevalence surveys","volume":"86","author":"Foster","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"R4-18-20240828","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/bjo.54.3.161","article-title":"Aetiology of the anatomical basis for primary angle-closure glaucoma. 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