{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:35:52Z","timestamp":1793399752201,"version":"4.5.0"},"reference-count":99,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>Optic disc drusen (ODD) is acellular calcified deposits found mainly in front of the lamina cribrosa within the optic nerve. It can cause chronic or acute vision loss. There has been progress in clinical diagnosis using ophthalmic multimodal imaging in recent years. We conducted a database search on PubMed and Google Scholar (April 2023) with no restrictions on publication year or language. We used the terms: (\u201coptic disc drusen\u201d) OR (\u201coptic nerve head drusen\u201d) OR (\u201cdrusen of optic nerve head\u201d). Other terms included gene, mutation, scleral canal, axonal transport, calcinosis, mitochondria, blood vessel, vasculature, visual field, vision, and optical coherence tomography to identify publications. Etiologically, ODD may stem from congenital genetic defects, aberrant axoplasmic transport, anatomical abnormalities, and mechanical factors during ocular duction. Clinically, ODD is linked to progressive visual field defects and vascular complications. Detection of deeply buried ODD can be challenging, but advances in optical coherence tomography make early identification possible. Structural changes, including retinal nerve fiber layer thinning, can be monitored. Increasing reports indicate vascular complications, including anterior ischemic optic neuropathy, in ODD patients. Currently, ODD-related visual field defects are not effectively treated, and observation remains the primary management approach. Future pathological discoveries or the establishment of animal models may provide new evidence for revealing the pathogenesis of ODD.<\/jats:p>","DOI":"10.4103\/ijo.ijo_937_24","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T11:00:29Z","timestamp":1745492429000},"page":"637-647","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Advances in origin, evolution, and pathogenesis of optic disc drusen: A narrative review"],"prefix":"10.4103","volume":"73","author":[{"given":"Xiyuan","family":"Liu","sequence":"first","affiliation":[{"name":"Ottawa-Shanghai Joint School of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"R1-20260422","first-page":"1","article-title":"Anatomische beitr\u00e4ge zur ophthalmologie","volume":"4","author":"M\u00fcller","year":"1858","journal-title":"Arch f\u00fcr Ophthalmol"},{"key":"R2-20260422","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/BF01927296","article-title":"Klinische und anatomische Untersuchungen \u00fcber Drusen im Sehnervenkopf","volume":"105","author":"Lauber","year":"1921","journal-title":"Graefes Archiv f\u00fcr Ophthalmologie"},{"key":"R3-20260422","first-page":"457","article-title":"Fluorescein angiography in the diagnosis of drusen of the disc","volume":"87","author":"Sanders","year":"1967","journal-title":"Trans Ophthalmol Soc U K (1962)"},{"key":"R4-20260422","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/s41433-022-02155-7","article-title":"Short-term progression of optic disc and macular changes in optic nerve head drusen","volume":"37","author":"Pilat","year":"2023","journal-title":"Eye (Lond)"},{"key":"R5-20260422","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/aos.15690","article-title":"Prevalence of optic disc drusen: A systematic review, meta-analysis and forecasting study","volume":"102","author":"Mukriyani","year":"2024","journal-title":"Acta Ophthalmol"},{"key":"R6-20260422","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0161-6420(81)80038-3","article-title":"Pathology and pathogenesis of drusen of the optic nervehead","volume":"88","author":"Tso","year":"1981","journal-title":"Ophthalmology"},{"key":"R7-20260422","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.ajo.2005.01.020","article-title":"The rate of visual field loss in optic nerve head drusen","volume":"139","author":"Lee","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"R8-20260422","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/S0161-6420(99)00708-3","article-title":"Are optic disc drusen inherited?","volume":"106","author":"Antcliff","year":"1999","journal-title":"Ophthalmology"},{"key":"R9-20260422","first-page":"391","article-title":"Drusen im Sehnervenkopf","volume":"17","author":"Lauber","year":"1907","journal-title":"Z Augenheilkd"},{"key":"R10-20260422","first-page":"734","article-title":"Ueber famili\u00e4res Vorkommen von Drusen der Papille","volume":"94","author":"Braun","year":"1935","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"R11-20260422","first-page":"1","article-title":"Drusen of the optic disk. 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