{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:23:14Z","timestamp":1787840594581,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cavitary disc anomalies, including optic disc pit (ODP), optic nerve coloboma (ODC), and morning glory disc anomaly (MGDA), are congenital conditions with distinct embryological origins and systemic associations. Hybrid features combining these anomalies are rare, complicating diagnosis and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To describe the clinical spectrum, multimodal imaging characteristics, and management strategies of hybrid cavitary disc anomalies, and to propose a novel classification system based on anatomical and physiological overlap.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective case series included 22 eyes from 17 patients seen at a tertiary care center over 19 months (June 2023\u2013December 2024). All underwent best-corrected visual acuity (BCVA) and fundus examination, multimodal imaging (color fundus photography and [optical coherence tomography] OCT), and neuroimaging when indicated. Findings were confirmed by a senior consultant with over 20 years of experience. Management tailored to visual prognosis and macular status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The median BCVA was Log MAR 0.30 \u00b1 1.13. Various anomalies include ODP with ODC and retinal choroidal coloboma in 10 eyes (45.5%), ODP with MGDA in 3 eyes (13.6%), ODC with RCC and bridging, coloboma in 3 eyes (13.6%), and ODC with MGDA in 2 eyes (9.1%). ODP with ODC, dual ODP with ODC and RCC, and dual ODP with ODC or RCC in 1 eye were each present in 1 eye (4.5). One patient had bilateral hybrid anomalies with maculopathy. Surgical intervention was required in 4 eyes (18.2%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Hybrid cavitary disc anomalies, including MGDA and ODP, present unique diagnostic and management challenges. This study provides insights into these rare conditions, emphasizing the need for further monitoring and research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_989_25","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:14:53Z","timestamp":1761668093000},"page":"1627-1632","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Hybrid cavitary disc anomaly \u2013 A case series and proposal of a novel classification system"],"prefix":"10.4103","volume":"73","author":[{"given":"Savithiri","family":"Palanivel","sequence":"first","affiliation":[{"name":"Department of Vitreoretina Services, Aravind Eye Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Department of Vitreoretina Services, Aravind Eye Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Maitra","sequence":"additional","affiliation":[{"name":"Department of Vitreoretina Services, Aravind Eye Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Rajamani","sequence":"additional","affiliation":[{"name":"Department of Vitreoretina Services, Aravind Eye Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"R1-20260419","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ogla.2021.09.008","article-title":"Cavitary optic disc anomaly","volume":"5","author":"Alawa","year":"2022","journal-title":"Ophthalmol Glaucoma"},{"key":"R2-20260419","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.ajo.2007.01.042","article-title":"Familial cavitary optic disk anomalies: Identification of a novel genetic locus","volume":"143","author":"Fingert","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"R3-20260419","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1001\/archneur.1980.00500530048006","article-title":"Cavitary developmental defects of the optic disc. 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A review of the pathogenesis and treatment options","volume":"1","author":"Moisseiev","year":"2015","journal-title":"Int J Retina Vitreous"},{"key":"R17-20260419","first-page":"1567","article-title":"Comparison of various surgical techniques for optic disc pit maculopathy: Vitrectomy with Internal limiting membrane (ILM) peeling alone versus inverted ILM flap \u2018plug\u2019versus autologous scleral \u2018plug\u2019","volume":"104","author":"Babu","year":"2020","journal-title":"Br J Ophthalmol"},{"key":"R18-20260419","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.4103\/ijo.IJO_189_21","article-title":"Outcomes of vitreoretinal surgery in retinal detachment associated with morning glory disc anomaly","volume":"69","author":"Sen","year":"2021","journal-title":"Indian J Ophthalmol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_989_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:25:38Z","timestamp":1787837138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_989_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,29]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_989_25","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,29]]},"assertion":[{"value":"2025-04-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}