{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:20:01Z","timestamp":1787840401423,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate if inflammation score (IS), calculated from the cornea, anterior chamber, iris, and vitreous, indicates endophthalmitis severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a prospective study, consecutive adults with a clinical diagnosis of post-cataract endophthalmitis within 6 weeks of surgery were recruited. Patients were allocated to IS-based primary treatment (IS &lt; 10: intravitreal injection and IS \u2265 10: vitrectomy) and randomized to two intravitreal antibiotics combinations (vancomycin + ceftazidime and vancomycin + imipenem). Undiluted vitreous microbiology work-up included culture susceptibility, polymerase chain reaction, Sanger sequencing, and targeted next-generation sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The average age of 175 people was 63.4 \u00b1 10.7 years and included 52.6% small incision cataract surgery and 47.4% phacoemulsification surgery. Severe endophthalmitis (IS \u2265 20), diagnosed in 27.4% of people, had a shorter time to symptoms (average 5.4 vs 8.7 days;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.018), poorer presenting vision (all \u2264 hand motion), higher culture positivity (50% vs 30.7%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.032), and higher Gram-negative bacterial infection (70.8% vs 46.2%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.042). For IS \u2265 20 discriminant and Gram-negative infection, Spearman\u2019s coefficient was 0.7 [\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001, 95% confidence interval (CI) 0.59\u20130.82], with an area under the receiver operating characteristic curve of 0.9 (95% CI 0.85\u20130.94,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001), a Youden index J of 0.74, a sensitivity of 87.2%, and a specificity of 87.5%. The final vision of &gt;20\/400 and &gt;20\/100 was regained in 50.2% and 29.1% of people, respectively. The susceptibility of common Gram-positive cocci and Gram-negative bacilli was the highest for vancomycin (95.0%) and colistin (88.6%), respectively. NGS detected polymicrobial infection in 88.5% of culture-negative endophthalmitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Higher inflammation scores indicated severe disease and Gram-negative infection in post-cataract endophthalmitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_997_23","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T01:04:32Z","timestamp":1703207072000},"page":"81-86","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Evaluating the utility of inflammation score in post-cataract surgery endophthalmitis. Results from a prospective study in India. 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