{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:12:16Z","timestamp":1790190736971,"version":"4.1.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"\n Background:<\/jats:title>\n COVID-19 pandemic posed a huge stress on health-care givers affecting their physical and mental health. Wellness strategies like yoga can improve flexibility, resilience, and outlook.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n The present study explored the effect of 8-week standard common yoga protocol (CYP) intervention on autonomic functions, emotional stress, oxidative stress, and inflammation markers in the nurse group of health-care givers.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n It is a randomized controlled trial where 50 nurses underwent CYP and 50 participated as controls. Anthropometric parameters, cardiovascular parameters, autonomic function including time and frequency domain parameters, biochemical parameters, and psychological stress using the questionnaire were assessed before and after 8-week CYP.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Total 88 nurses completed the study with 42 and 46 participants, respectively, in the CYP and control groups. CYP intervention resulted in a significant reduction in cardiovascular parameters systolic blood pressure, diastolic blood pressure, mean arterial pressure, pulse pressure, and rate pressure product (\n P<\/jats:italic>\n < 0.001,\n P<\/jats:italic>\n < 0.001,\n P<\/jats:italic>\n < 0.001,\n P<\/jats:italic>\n < 0.001, and\n P<\/jats:italic>\n = 0.002, respectively), perceived stress score and Depression, Anxiety, and Stress Scale psychological variables of depression, anxiety, and stress, and serum lipid parameters compared to the control group. CYP significantly increased total power, low frequency, high frequency, root mean square of successive differences between adjacent NN intervals, change in successive normal sinus (NN) intervals exceeds 50 ms, and pNN50% (\n P<\/jats:italic>\n < 0.001,\n P<\/jats:italic>\n = 0.006,\n P<\/jats:italic>\n = 0.006,\n P<\/jats:italic>\n = 0.039,\n P<\/jats:italic>\n < 0.001, and\n P<\/jats:italic>\n = 0.013, respectively) suggesting improved resting autonomic modulation and parasympathodominance due to higher vagal efferent activity. There were significant reductions in serum cortisol, tumor necrosis factor-alpha, interleukin (IL)-1, and IL-6 in both the groups. Serum telomerase significantly reduced (\n P<\/jats:italic>\n = 0.024) and total antioxidant capacity (\n P<\/jats:italic>\n = 0.036) increased in the CYP group post intervention.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n CYP intervention was beneficial in improving psychophysiological, autonomic, and biochemical profile of the nurse group of health-care workers.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijoy.ijoy_127_23","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T06:03:59Z","timestamp":1717135439000},"page":"79-89","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["COVID-19-induced Stress in Health-care Workers: Effect of 8-week Common Yoga Protocol on Autonomic Function and Inflammatory and Oxidative Stress Markers"],"prefix":"10.4103","volume":"16","author":[{"given":"Vivek Kumar","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, PDU Medical College, Rajkot, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Kathrotia","sequence":"additional","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, PDU Medical College, Rajkot, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradip B.","family":"Barde","sequence":"additional","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, PDU Medical College, Rajkot, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, PDU Medical College, Rajkot, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Chitturi","sequence":"additional","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, PDU Medical College, Rajkot, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, PDU Medical College, Rajkot, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauravi","family":"Dhruva","sequence":"additional","affiliation":[{"name":"Department of Pathology, PDU Medical College, Rajkot, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghanshyam","family":"Kavathia","sequence":"additional","affiliation":[{"name":"Department of Microbiology, PDU Medical College, Rajkot, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"R1-20260512","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/jama.2020.12839","article-title":"Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): A review","volume":"324","author":"Wiersinga","year":"2020","journal-title":"JAMA"},{"key":"R2-20260512","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1001\/dmp.2012.2","article-title":"The H1N1 crisis: A case study of the integration of mental and behavioral health in public health crises","volume":"6","author":"Pfefferbaum","year":"2012","journal-title":"Disaster Med Public Health Prep"},{"key":"R3-20260512","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1056\/NEJMp2008017","article-title":"Mental health and the COVID-19 pandemic","volume":"383","author":"Pfefferbaum","year":"2020","journal-title":"N Engl J Med"},{"key":"R4-20260512","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.jaip.2020.04.001","article-title":"Clinician wellness during the COVID-19 pandemic: Extraordinary times and unusual challenges for the allergist\/immunologist","volume":"8","author":"Bansal","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"R5-20260512","first-page":"117","article-title":"Yoga on our minds: A systematic review of yoga for neuropsychiatric disorders","volume":"3","author":"Balasubramaniam","year":"2012","journal-title":"Front Psychiatry"},{"key":"R6-20260512","doi-asserted-by":"crossref","first-page":"410","DOI":"10.4103\/psychiatry.IndianJPsychiatry_398_17","article-title":"5-HTTLPR and MTHFR 677C>T polymorphisms and response to yoga-based lifestyle intervention in major depressive disorder: A randomized active-controlled trial","volume":"60","author":"Tolahunase","year":"2018","journal-title":"Indian J Psychiatry"},{"key":"R7-20260512","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1177\/2156587213499918","article-title":"Yoga as an alternative and complementary approach for arthritis: A systematic review","volume":"19","author":"Sharma","year":"2014","journal-title":"J Evid Based Complementary Altern Med"},{"key":"R8-20260512","doi-asserted-by":"crossref","first-page":"846231","DOI":"10.3389\/fpubh.2022.846231","article-title":"Content, structure, and delivery characteristics of yoga interventions for managing hypertension: A systematic review and meta-analysis of randomized controlled trials","volume":"10","author":"Nalbant","year":"2022","journal-title":"Front Public Health"},{"key":"R9-20260512","article-title":"Yoga practitioners exhibit higher parasympathetic activity and baroreflex sensitivity and better adaptability to 40 mm hg lower-body negative pressure","volume":"31","author":"Anasuya","year":"2021","journal-title":"Int J Yoga Therap"},{"key":"R10-20260512","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.3389\/fpsyg.2020.02259","article-title":"Effect of an 8-week yoga-based lifestyle intervention on psycho-neuro-immune axis, disease activity, and perceived quality of life in rheumatoid arthritis patients: A randomized controlled trial","volume":"11","author":"Gautam","year":"2020","journal-title":"Front Psychol"},{"key":"R11-20260512","doi-asserted-by":"crossref","first-page":"7928981","DOI":"10.1155\/2017\/7928981","article-title":"Impact of yoga and meditation on cellular aging in apparently healthy individuals: A prospective, open-label single-arm exploratory study","volume":"2017","author":"Tolahunase","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"R12-20260512","first-page":"32","article-title":"Effects of yoga on stress management in healthy adults: A systematic review","volume":"17","author":"Chong","year":"2011","journal-title":"Altern Ther Health Med"},{"key":"R13-20260512","doi-asserted-by":"crossref","first-page":"108644","DOI":"10.1016\/j.diabres.2020.108644","article-title":"Effect of yoga intervention on biochemical, oxidative stress markers, inflammatory markers and sleep quality among subjects with type 2 diabetes in South India: Results from the SATYAM project","volume":"172","author":"Viswanathan","year":"2021","journal-title":"Diabetes Res Clin Pract"},{"key":"R14-20260512","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Heart rate variability: Standards of measurement, physiological interpretation and clinical use","volume":"93","year":"1996","journal-title":"Circulation"},{"key":"R15-20260512","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress","volume":"24","author":"Cohen","year":"1983","journal-title":"J Health Soc Behav"},{"key":"R16-20260512","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0005-7967(94)00075-U","article-title":"The structure of negative emotional states: Comparison of the depression anxiety stress scales (DASS) with the beck depression and anxiety inventories","volume":"33","author":"Lovibond","year":"1995","journal-title":"Behav Res Ther"},{"key":"R17-20260512","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1186\/s13063-020-04402-2","article-title":"Effect of voluntary breathing exercises on stable coronary artery disease in heart rate variability and rate-pressure product: A study protocol for a single-blind, prospective, randomized controlled trial","volume":"21","author":"Wu","year":"2020","journal-title":"Trials"},{"key":"R18-20260512","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4103\/ijoy.IJOY_29_20","article-title":"Autonomic tone and baroreflex sensitivity during 70\u00b0 head-up tilt in yoga practitioners","volume":"13","author":"Anasuya","year":"2020","journal-title":"Int J Yoga"},{"key":"R19-20260512","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fpubh.2017.00258","article-title":"An overview of heart rate variability metrics and norms","volume":"5","author":"Shaffer","year":"2017","journal-title":"Front Public Health"},{"key":"R20-20260512","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1136\/heart.83.3.290","article-title":"Patients with uncomplicated coronary artery disease have reduced heart rate variability mainly affecting vagal tone","volume":"83","author":"Wennerblom","year":"2000","journal-title":"Heart"},{"key":"R22-20260512","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/0973-6131.171714","article-title":"Impact of short-term practice of yoga on heart rate variability","volume":"9","author":"Vinay","year":"2016","journal-title":"Int J Yoga"},{"key":"R23-20260512","first-page":"37","article-title":"Effectiveness of yoga lifestyle on lipid metabolism in a vulnerable population-a community based multicenter randomized controlled trial","volume":"8","author":"Nagarathna","year":"2021","journal-title":"Medicines (Basel)"},{"key":"R24-20260512","first-page":"37","article-title":"Lipid profile of coronary risk subjects following yogic lifestyle intervention","volume":"51","author":"Mahajan","year":"1999","journal-title":"Indian Heart J"},{"key":"R25-20260512","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s12291-008-0080-9","article-title":"Influence of pranayamas and yoga-asanas on serum insulin, blood glucose and lipid profile in type 2 diabetes","volume":"23","author":"Singh","year":"2008","journal-title":"Indian J Clin Biochem"},{"key":"R26-20260512","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1093\/tbm\/iby060","article-title":"Comparative efficacy of a 12 week yoga-based lifestyle intervention and dietary intervention on adipokines, inflammation, and oxidative stress in adults with metabolic syndrome: A randomized controlled trial","volume":"9","author":"Yadav","year":"2019","journal-title":"Transl Behav Med"},{"key":"R27-20260512","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1089\/acm.2005.11.267","article-title":"A brief but comprehensive lifestyle education program based on yoga reduces risk factors for cardiovascular disease and diabetes mellitus","volume":"11","author":"Bijlani","year":"2005","journal-title":"J Altern Complement Med"},{"key":"R28-20260512","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.pa.35.040195.002221","article-title":"Catecholamine influences and sympathetic neural modulation of immune responsiveness","volume":"35","author":"Madden","year":"1995","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R29-20260512","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1073\/pnas.0803237105","article-title":"Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia","volume":"105","author":"Rosas-Ballina","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R30-20260512","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1314.001","article-title":"Protection and damage from acute and chronic stress: Allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders","volume":"1032","author":"McEwen","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"R31-20260512","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1089\/acm.2014.0298","article-title":"Telomerase activity and cellular aging might be positively modified by a yoga-based lifestyle intervention","volume":"21","author":"Kumar","year":"2015","journal-title":"J Altern Complement Med"},{"key":"R32-20260512","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.dsx.2019.01.011","article-title":"Assessment of autonomic functions and its association with telomerase level, oxidative stress and inflammation in complete glycemic spectrum- an exploratory study","volume":"13","author":"Sharma","year":"2019","journal-title":"Diabetes Metab Syndr"},{"key":"R33-20260512","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0079-6123(08)62131-7","article-title":"Circuits and mechanisms governing hypothalamic responses to stress: A tale of two paradigms","volume":"122","author":"Sawchenko","year":"2000","journal-title":"Prog Brain Res"},{"key":"R34-20260512","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0079-6123(00)26014-7","article-title":"Stress impairs prefrontal cortical function in rats and monkeys: Role of dopamine D1 and norepinephrine alpha-1 receptor mechanisms","volume":"126","author":"Arnsten","year":"2000","journal-title":"Prog Brain Res"},{"key":"R35-20260512","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0079-6123(08)62150-0","article-title":"Specificity in the organization of the autonomic nervous system: A basis for precise neural regulation of homeostatic and protective body functions","volume":"122","author":"J\u00e4nig","year":"2000","journal-title":"Prog Brain Res"},{"key":"R36-20260512","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/ecam\/nem087","article-title":"Iyengar yoga increases cardiac parasympathetic nervous modulation among healthy yoga practitioners","volume":"4","author":"Khattab","year":"2007","journal-title":"Evid Based Complement Alternat Med"},{"key":"R37-20260512","doi-asserted-by":"crossref","first-page":"813664","DOI":"10.3389\/fpubh.2022.813664","article-title":"Perceived stress, resilience, and wellbeing in seasoned Isha yoga practitioners compared to matched controls during the COVID-19 pandemic","volume":"10","author":"Upadhyay","year":"2022","journal-title":"Front Public Health"},{"key":"R38-20260512","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1177\/00207640211006742","article-title":"Yoga and music intervention to reduce depression, anxiety, and stress during COVID-19 outbreak on healthcare workers","volume":"68","author":"Vajpeyee","year":"2022","journal-title":"Int J Soc Psychiatry"},{"key":"R39-20260512","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3390\/healthcare10061027","article-title":"Systematic review of mind-body modalities to manage the mental health of healthcare workers during the COVID-19 Era","volume":"10","author":"Kwon","year":"2022","journal-title":"Healthcare (Basel)"},{"key":"R40-20260512","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.explore.2009.10.004","article-title":"Top-down and bottom-up mechanisms in mind-body medicine: Development of an integrative framework for psychophysiological research","volume":"6","author":"Taylor","year":"2010","journal-title":"Explore (NY)"},{"key":"R41-20260512","doi-asserted-by":"crossref","first-page":"41411","DOI":"10.1038\/srep41411","article-title":"Combination of IL-6 and sIL-6R differentially regulate varying levels of RANKL-induced osteoclastogenesis through NF-\u03baB, ERK and JNK signaling pathways","volume":"7","author":"Feng","year":"2017","journal-title":"Sci Rep"},{"key":"R42-20260512","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1146\/annurev-physiol-030212-183653","article-title":"Aging, cellular senescence, and cancer","volume":"75","author":"Campisi","year":"2013","journal-title":"Annu Rev Physiol"}],"container-title":["International Journal of Yoga"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijoy.ijoy_127_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:25:32Z","timestamp":1786724732000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijoy.ijoy_127_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijoy.ijoy_127_23","relation":{},"ISSN":["0973-6131","2231-2714"],"issn-type":[{"value":"0973-6131","type":"print"},{"value":"2231-2714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2023-07-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}