{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:22:19Z","timestamp":1793049739414,"version":"4.5.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION:<\/jats:title>\n The autoimmune disorder, oral lichen planus (OLP), primarily affects oral mucous membranes. Current drug treatments are only palliative and have serious side effects. Pomegranate has been used as a potential herbal remedy for the treatment of OLP.<\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n \n The study consisted of a sample size of 30 individuals who were diagnosed with symptomatic OLP based on both clinical and histological evidence and were equally assigned to Group A (4% topical\n Punica granatum<\/jats:italic>\n seed extract gel, which has been customized for this particular study purpose only) and Group B (0.1% topical steroid). All patients were evaluated for the outcome criteria of pain, burning sensation, and lesion size.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n In the present study, results were highly statistically significant (\n P<\/jats:italic>\n = 0.001) in intragroup observation for both Group A and Group B from baseline to the end of 30 days of follow-up for all three parameters. There was no statistically significant difference between groups for each week of follow-up.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n \n P. granatum<\/jats:italic>\n has been used in very few studies, but this is one of the few where a gel made from\n P. granatum<\/jats:italic>\n seed extract is used as an oral gel. In conclusion, it can be said that topical\n P. granatum<\/jats:italic>\n extract gel is as good as topical corticosteroids at getting rid of the signs and symptoms of OLP, so it can be used as an alternative treatment.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijp.ijp_107_23","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T11:52:17Z","timestamp":1714477937000},"page":"84-90","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["The efficacy of Punica granatum extract gel in the treatment of symptomatic oral lichen planus in an Indian population: A clinical study"],"prefix":"10.4103","volume":"56","author":[{"given":"Subharina","family":"Mahapatra","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology, Bharati Vidyapeeth (Deemed to be) University, Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjula","family":"Hebbale","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Bharati Vidyapeeth (Deemed to be) University, Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Mhapuskar","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Bharati Vidyapeeth (Deemed to be) University, Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajshekhar","family":"Halli","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be) University, Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Bharati Vidyapeeth (Deemed to be) University, Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"R1-20240903","doi-asserted-by":"crossref","first-page":"731093","DOI":"10.3389\/fpsyt.2021.731093","article-title":"Case report:Treatment of oral lichen planus with a focus on psychological methods","volume":"12","author":"Song","year":"2021","journal-title":"Front Psychiatry"},{"key":"R2-20240903","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5005\/jp-journals-10031-1238","article-title":"Oral lichen planus \u2013A brief review on treatment modalities","volume":"8","author":"Shirke","year":"2018","journal-title":"J Contemp 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