{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:19:10Z","timestamp":1787750350265,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>To evaluate the association between serum acetaminophen levels and hepatorenal function in patients receiving therapeutic doses of acetaminophen over a short period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>A prospective observational study was conducted in the department of physical medicine and rehabilitation at a tertiary care hospital in Tripura, India, from August 2021 to July 2022. A total of 109 patients receiving therapeutic doses of acetaminophen were enrolled. Blood samples were collected on day 1 (within 4 h of the first dose) and day 7 of continuous administration. Plasma acetaminophen concentrations were estimated using liquid chromatography\u2013mass spectrometry. Hepatic markers (serum glutamic-oxaloacetic transaminase [SGOT], serum glutamic-pyruvic transaminase [SGPT], total bilirubin, total protein, alkaline phosphatase, albumin, and globulin), and renal markers (serum urea, creatinine, and uric acid) were measured using a fully automated biochemical analyzer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Mean plasma acetaminophen levels increased significantly from 15.09 \u00b1 6.25 \u03bcg\/ml on day 1 to 17.08 \u00b1 7.34 \u03bcg\/ml on day 7 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). Mild but statistically significant elevations in SGOT and SGPT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) were observed. Serum urea (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.013) and creatinine (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.031) also showed minor increases, although all values remained within normal reference ranges and were clinically insignificant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Therapeutic use of acetaminophen over a short period may lead to subtle hepatorenal changes. While these alterations are not clinically significant, periodic monitoring is advisable in patients requiring prolonged or repeated use. Further studies are warranted to evaluate long-term safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijp.ijp_1130_25","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:00:25Z","timestamp":1782410425000},"page":"472-477","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Association of serum acetaminophen levels with hepatorenal toxicity: A prospective observational study in Tripura, India"],"prefix":"10.4103","volume":"58","author":[{"given":"Debasis","family":"Ray","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Agartala Government Medical College, Agartala, Tripura, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bidhan","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Agartala Government Medical College, Agartala, Tripura, 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