{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:23:36Z","timestamp":1787775816449,"version":"build-2784847793"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:p>\n                    Polymyxin B is a last-resort antibiotic used to treat multidrug-resistant (MDR) Gram-negative infections. While nephrotoxicity and neurotoxicity are well-documented, severe dermatologic adverse reactions such as toxic epidermal necrolysis (TEN) are exceedingly uncommon but clinically significant. A 54-year-old hypertensive male underwent an emergency Bentall procedure for DeBakey type I aortic dissection. The patient developed acute kidney injury requiring dialysis. The patient subsequently developed polymyxin B-sensitive\n                    <jats:italic toggle=\"yes\">Acinetobacter lwoffii<\/jats:italic>\n                    septicemia, for which intravenous polymyxin B was initiated. On day 6 of therapy, the patient developed a widespread erythematous rash that progressed to bullous eruptions and skin sloughing involving over 30% body surface area. A clinical diagnosis of TEN was made. Polymyxin B was discontinued immediately, and the patient was managed with corticosteroids and wound care. The patient demonstrated complete clinical recovery. This case underscores the importance of heightened clinical suspicion for polymyxin B-induced toxic epidermal necrolysis and early withdrawal of the offending agent to ensure prompt detection and recovery.\n                  <\/jats:p>","DOI":"10.4103\/ijp.ijp_1139_25","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T07:00:24Z","timestamp":1772434824000},"page":"156-158","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["A rare drug reaction: Toxic epidermal necrolysis following polymyxin B administration in a post-Bentall procedure"],"prefix":"10.4103","volume":"58","author":[{"given":"Bhavin B.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Bhailal Amin General Hospital, Vadodara, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachana B.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Smt. Bhikhiben Kanjibhai Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisarg R.","family":"Hajariwala","sequence":"additional","affiliation":[{"name":"Department of Medical Services, Bhailal Amin General Hospital, Vadodara, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Maheshwari","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Bhailal Amin General Hospital, Vadodara, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Ganju","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Bhailal Amin General Hospital, Vadodara, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Bhailal Amin General Hospital, Vadodara, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"R1-20260302","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1056\/NEJM199411103311906","article-title":"Severe adverse cutaneous reactions to drugs","volume":"331","author":"Roujeau","year":"1994","journal-title":"N Engl J Med"},{"key":"R2-20260302","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1586\/eci.11.66","article-title":"The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"7","author":"Mockenhaupt","year":"2011","journal-title":"Expert Rev Clin Immunol"},{"key":"R3-20260302","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1111\/bjd.14530","article-title":"U. 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