{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:19:26Z","timestamp":1787750366135,"version":"build-2784847793"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>Gut dysbiosis is widely recognized to serve as crucial role in the etiology of inflammatory bowel disease (IBD). This research evaluates the ability of a stabilized rice bran extract (RBE) to modulate positively microbial dysbiosis in an experimentally induced IBD model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>Rats were given 5% dextran sulfate sodium (DSS) in drinking water during a week to cause colitis. RBE was administered to the rats with a daily dosage of 100 mg\/kg, 1 week before feeding them with DSS and continued during DSS treatment. Fecal samples were then collected to assess alterations in the chosen microbial phyla, while colon samples were processed for histological and biochemical assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>The colonic expression of toll-like receptor 4 (TLR4), nuclear factor kappa \u03b2 (NF-\u03baB), tumor necrosis factor alpha, and interlukin-17 (IL-17) was significantly elevated when DSS induced colitis, resulting in significant histopathological damage and a decrease in the amount of IL-10. Furthermore, DSS caused the colonic tight junction (TJ) protiens mRNA expression to drop dramatically. All undesirable changes induced by DSS tended to be reversed by RBE. Moreover, RBE beneficially modulated the gut microbiota by restoring various bacteria to their normal levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The current research demonstrated the potential protective effect of RBE against colonic inflammation through modulating microbiota dysbiosis, TJ protein dysfunction, and TLR4\/NF-\u03baB signaling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijp.ijp_1191_25","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:00:25Z","timestamp":1782410425000},"page":"457-467","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Rice bran extract ameliorates experimental colitis by modulating gut dysbiosis and toll-like receptor 4\/nuclear factor kappa \u03b2 signaling"],"prefix":"10.4103","volume":"58","author":[{"given":"Hagar M.","family":"Shendy","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Egypt"},{"name":"Egyptian Drug Authority (EDA), Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omneya","family":"Galal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ahram Canadian University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa","family":"Wadie","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourtan F.","family":"Abdeltawab","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Helal","sequence":"additional","affiliation":[{"name":"Health Tech, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed T.","family":"Khayyal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"R1-20260626","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s41232-024-00321-w","article-title":"Metabolic network of the gut microbiota in inflammatory bowel disease","volume":"44","author":"Sugihara","year":"2024","journal-title":"Inflamm Regen"},{"key":"R2-20260626","doi-asserted-by":"crossref","first-page":"e1800080","DOI":"10.1002\/mnfr.201800080","article-title":"Propolis from different geographic origins decreases intestinal inflammation and Bacteroides spp","volume":"62","author":"Wang","year":"2018","journal-title":"populations in a model of DSS-induced colitis. 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