{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:18:55Z","timestamp":1787750335713,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"Abstract:<\/jats:title>\n \n BACKGROUND:<\/jats:title>\n Dapsone-induced hemolysis is well described in the literature, especially in glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency. However, it is reported rarely with normal G6PD levels.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVES:<\/jats:title>\n \n The objective of the study was to describe the association between dapsone and fall in oxygen saturation (SpO\n 2<\/jats:sub>\n ) and hemoglobin after intake of the drug.\n <\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n \n All outpatients and inpatients receiving dapsone who presented with breathlessness, fall in SpO\n 2<\/jats:sub>\n , hemolysis, and fall in hemoglobin were included in the study. Patients who were started on dapsone were asked to measure the SpO\n 2<\/jats:sub>\n regularly and observed for any breathlessness. Complete blood count (CBC) and liver function test (LFT) were repeated, and a reticulocyte test was done after 1 week of dapsone.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Twelve cases (5 female and 7 male) with a mean age of 47 years, ranging from 22 to 83 years, presented with various dermatological conditions treated with dapsone. SpO\n 2<\/jats:sub>\n fell in all cases, of which eight cases developed breathlessness after starting dapsone. Nine cases developed a reduction in hemoglobin (Hb) with increased reticulocyte counts. The mean decrease in Hb was 2.74 mg\/dL. LFT was deranged postdapsone in six cases. Dapsone was stopped in all cases, following which Hb level improved, and there was relief of breathlessness with normal SpO\n 2<\/jats:sub>\n . Confirmation was done by drug provocation with dapsone.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n \n Baseline CBC and SpO\n 2<\/jats:sub>\n with frequent repetition every week, along with reticulocyte count, are essential to look for dapsone induced hemolysis and methemoglobinemia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijp.ijp_1323_25","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:00:21Z","timestamp":1782410421000},"page":"468-471","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Dapsone induced hemolysis and drop in saturation in normal glucose-6-phosphate dehydrogenase level patients \u2013 alarming presentation of poor man\u2019s drug: A series of 12 cases and review of literature"],"prefix":"10.4103","volume":"58","author":[{"given":"Swetalina","family":"Pradhan","sequence":"first","affiliation":[{"name":"Department of Dermatology, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Dash","sequence":"additional","affiliation":[{"name":"Department of Dermatology, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"R1-20260626","doi-asserted-by":"crossref","first-page":"469","DOI":"10.4103\/0019-5154.190105","article-title":"Anti-inflammatory and immunomodulatory effects of antibiotics and their use in dermatology","volume":"61","author":"Pradhan","year":"2016","journal-title":"Indian J Dermatol"},{"key":"R2-20260626","doi-asserted-by":"crossref","first-page":"e05700","DOI":"10.1002\/ccr3.5700","article-title":"Dapsone induced hemolysis in a patient with Hansen's disease and G6PD deficiency: A preventable peril","volume":"10","author":"Ghorui","year":"2022","journal-title":"Clin Case 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Transplant"},{"key":"R6-20260626","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40064-015-0816-y","article-title":"Dapsone induced hemolysis in a patient with ANCA associated glomerulonephritis and normal G6PD level and implications for clinical practice: Case report and review of the literature","volume":"4","author":"Lee","year":"2015","journal-title":"Springerplus"},{"key":"R7-20260626","first-page":"1058","article-title":"Efficacy of systemic dapsone treatment for pyoderma gangrenosum: A retrospective review","volume":"17","author":"Din","year":"2018","journal-title":"J Drugs Dermatol"},{"key":"R8-20260626","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1186\/s12887-019-1882-z","article-title":"G6PD genetic variations in neonatal hyperbilirubinemia in Indonesian deutromalay population","volume":"19","author":"Wisnumurti","year":"2019","journal-title":"BMC Pediatr"},{"key":"R9-20260626","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12881-014-0093-6","article-title":"Genetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya","volume":"15","author":"Shah","year":"2014","journal-title":"BMC Med Genet"},{"key":"R10-20260626","doi-asserted-by":"crossref","first-page":"305","DOI":"10.47276\/lr.83.3.305","article-title":"Hemolytic anemia in patients receiving daily dapsone for the treatment of leprosy","volume":"83","author":"Deps","year":"2012","journal-title":"Lepr Rev"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_1323_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:25:49Z","timestamp":1787747149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_1323_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijp.ijp_1323_25","relation":{},"ISSN":["0253-7613","1998-3751"],"issn-type":[{"value":"0253-7613","type":"print"},{"value":"1998-3751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-12-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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