{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:25:08Z","timestamp":1789687508839,"version":"4.0.1"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>Liver derangement underlies the development of metabolic syndrome in perimenopause. Previously, we have observed that durva swaras (DS) improved metabolic-associated fatty liver disease (MAFLD) and abnormal liver enzymes (aspartate aminotransferase and alanine aminotransferase) along with other complications of menopause in ovariectomized rats. We aimed to decipher the hepatoprotective mechanisms of DS in acetaminophen (APAP)-induced liver injury model, which is analogous to the pathophysiology of MAFLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>\n                      Male Swiss albino mice were distributed into three groups at random. Group I (Control) was administered with vehicle (distilled water) for 7 days. Group II (APAP) received vehicle for the first 6 days and APAP (350 mg\/kg - single dose) on the 7\n                      <jats:sup>th<\/jats:sup>\n                      day. Group III (APAP + D) received test compound DS (quality complied) at a dose of 133 mg\/kg for 6 days and APAP (350 mg\/kg - single dose) on the 7\n                      <jats:sup>th<\/jats:sup>\n                      day. Subsequently, blood and liver tissues were subjected to biochemical, ultrastructural, and gene expression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>DS pretreatment protected the liver from APAP-induced disruption of sinusoids and necrosis. DS prevented the elevation of liver enzymes \u2013 AST and ALT induced by APAP. Importantly, DS inhibited the APAP-elicited increase in messenger ribonucleic acid levels of hepatic nuclear factor-kappa beta (NF-\u03baB) and pro-inflammatory cytokines, namely interleukin-1 beta, interleukin 6, and tumor necrosis factor-alpha. Moreover, DS activated gene expression of nuclear factor erythroid 2-related factor 2 and liver-X-receptor-alpha (LXR-\u03b1) to combat the liver damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>DS hinders APAP-induced liver damage by activating LXR-\u03b1 and inhibiting the NF-\u03baB-associated pro-inflammatory cytokine gene expression. These observations confirm the protective role of DS in metabolic dysfunction-associated liver conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijp.ijp_133_24","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T15:17:28Z","timestamp":1725895048000},"page":"260-267","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacological benefits of durva swaras (Cynodon dactylon L. Pers.) administration in APAP-induced liver injury model of mice \u2013 Assessment by metabolic and inflammatory markers"],"prefix":"10.4103","volume":"56","author":[{"given":"B.","family":"Sindhoora","sequence":"first","affiliation":[{"name":"Division of Drug and Food Safety, ICMR-National Institute of Nutrition, Tarnaka, Jamai-Osmania, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Singh","sequence":"additional","affiliation":[{"name":"Senior Scientist, Department of Innovation and R&D, Sarvotham Care Limited, Secunderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathish Kumar","family":"Mungamuri","sequence":"additional","affiliation":[{"name":"Division of Drug and Food Safety, ICMR-National Institute of Nutrition, Tarnaka, Jamai-Osmania, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh Kumar","family":"Bharatraj","sequence":"additional","affiliation":[{"name":"Division of Drug and Food Safety, ICMR-National Institute of Nutrition, Tarnaka, Jamai-Osmania, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"R1-20240909","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/GME.0000000000002133","article-title":"Menopause is associated with increased prevalence of nonalcoholic fatty liver disease:A systematic review and meta-analysis","volume":"30","author":"Jaroenlapnopparat","year":"2023","journal-title":"Menopause"},{"key":"R2-20240909","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3109\/01443615.2016.1154516","article-title":"Changes of liver enzymes and triglyceride during the menopausal transition in Japanese women","volume":"36","author":"Matsui","year":"2016","journal-title":"J Obstet Gynaecol"},{"key":"R3-20240909","doi-asserted-by":"crossref","first-page":"111976","DOI":"10.1016\/j.biopha.2021.111976","article-title":"Pharmacological properties of Durva Swaras (Cynodon dactylon L. 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