{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:19:11Z","timestamp":1787750351574,"version":"build-2784847793"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      Diethylnitrosamine (DEN) is a potent environmental carcinogen commonly found in cigarette smoke and polluted air, which is strongly associated with the initiation and progression of lung cancer through oxidative stress, inflammation, and dysregulated cell signaling. Alloimperatorin, a bioactive furanocoumarin compound isolated from\n                      <jats:italic toggle=\"yes\">Angelica dahurica<\/jats:italic>\n                      , has demonstrated anti-inflammatory, antioxidant, and anticancer potential. The current study was designed to explore the chemoprotective effect of alloimperatorin against DEN-induced lung cancer in rats and explore the underlying signaling pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>Lung carcinogenesis was induced in male Wistar rats via intraperitoneal administration of DEN, and rats received the oral administration of alloimperatorin for 8 weeks. The lung function, body weight, tumor markers, phase I, phase II, polyamine, inflammatory parameters, inflammatory cytokines, and antioxidant enzymes were assessed. Quantitative histopathological analysis and histopathological observation were done in the lung tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Alloimperatorin significantly ameliorated the tumor burden, tumor number, mean tumor size, and improved histological architecture. Alloimperatorin ameliorate the level of tumor markers (5\u2019-nucleotidase, aryl hydrocarbon hydroxylase, adenosine deaminase, lactate dehydrogenase, Hexosamine, Hexose), hematological parameters (total leucocytes, lymphocytes, total white blood cells count, neutrophils, monocytes, red blood cells counts), pro-inflammatory cytokines (tumor necrosis factor-alpha, L-1\u03b2, interleukin 4 [IL-4], IL-6, IL-10, IL-18), inflammatory parameters (cyclooxygenase-2, PGE\n                      <jats:sub>2<\/jats:sub>\n                      , vascular endothelial growth factor, nuclear kappa B factor [NF-\u03baB]), apoptosis (Bax, Bcl-2, caspase-3) while restoring antioxidant enzyme (superoxide dismutase, catalase, glutathione (GSH) peroxidase, GSH, malonaldehyde) activities. In addition, it enhanced the level of HO-1 and Nrf\n                      <jats:sub>2<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>\n                      Alloimperatorin ameliorate the lung cancer via alteration of the NF-\u03baB and Nrf\n                      <jats:sub>2<\/jats:sub>\n                      signalling pathway.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijp.ijp_1353_25","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:00:20Z","timestamp":1782410420000},"page":"430-441","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Alloimperatorin attenuates lung tumor progression by targeting oxidative stress and nuclear kappa B factor\/Nrf2 pathway dysregulation"],"prefix":"10.4103","volume":"58","author":[{"given":"Guolong","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Emergency, Ganzhou Fifth People\u2019s Hospital (Ganzhou Respiratory Institute), Ganzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuolong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency, Ganzhou Fifth People\u2019s Hospital, Ganzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Emergency, Ganzhou Fifth People\u2019s Hospital, Ganzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Emergency, Ganzhou Fifth People\u2019s Hospital, Ganzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangzhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency, Ganzhou Fifth People\u2019s Hospital (Ganzhou Respiratory Institute), Ganzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"R1-20260626","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1002\/cncr.35128","article-title":"Lung cancer statistics 2023","volume":"130","author":"Kratzer","year":"2024","journal-title":"Cancer"},{"key":"R2-20260626","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1097\/CM9.0000000000002529","article-title":"Global burden and trends of lung cancer incidence and mortality","volume":"136","author":"Li","year":"2023","journal-title":"Chin Med J (Engl)"},{"key":"R3-20260626","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/CM9.0000000000002108","article-title":"Cancer statistics in China and United States, 2022: Profiles, trends, and determinants","volume":"135","author":"Xia","year":"2022","journal-title":"Chin Med J (Engl)"},{"key":"R5-20260626","first-page":"2012","year":"2013","journal-title":"2013: International Agency for Research on Cancer, World Health Organization"},{"key":"R6-20260626","doi-asserted-by":"crossref","first-page":"355","DOI":"10.21037\/atm-20-7770","article-title":"Chemoprotective effect of atorvastatin against benzo(a)pyrene-induced lung cancer via the inhibition of oxidative stress and inflammatory parameters","volume":"9","author":"Du","year":"2021","journal-title":"Ann Transl Med"},{"key":"R7-20260626","doi-asserted-by":"crossref","first-page":"111650","DOI":"10.1016\/j.biopha.2021.111650","article-title":"Phytochemicals in cancer and their effect on the PI3K\/AKT-mediated cellular signalling","volume":"139","author":"Issinger","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"R8-20260626","doi-asserted-by":"crossref","first-page":"1276209","DOI":"10.3389\/fphar.2023.1276209","article-title":"Nanotechnological synergy of mangiferin and curcumin in modulating PI3K\/Akt\/mTOR pathway: A novel front in ovarian cancer precision therapeutics","volume":"14","author":"Alharbi","year":"2023","journal-title":"Front Pharmacol"},{"key":"R9-20260626","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41392-021-00828-5","article-title":"Targeting PI3K\/Akt signal transduction for cancer therapy","volume":"6","author":"He","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"R10-20260626","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol Cancer"},{"key":"R11-20260626","doi-asserted-by":"crossref","first-page":"5413","DOI":"10.1002\/jcp.29429","article-title":"Targeting Wnt\/\u03b2-catenin and PI3K\/Akt\/mTOR pathways in T-cell acute lymphoblastic leukemia","volume":"235","author":"Evangelisti","year":"2020","journal-title":"J Cell Physiol"},{"key":"R12-20260626","doi-asserted-by":"crossref","first-page":"14299","DOI":"10.1080\/21655979.2022.2084243","article-title":"In vivo and in vitro studies of alloimperatorin induced autophagy in cervical cancer cells via reactive oxygen species pathway","volume":"13","author":"yingBai","year":"2022","journal-title":"Bioengineered"},{"key":"R13-20260626","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1139\/bcb-2021-0399","article-title":"Alloimperatorin activates apoptosis, ferroptosis, and oxeiptosis to inhibit the growth and invasion of breast cancer cells in vitro","volume":"100","author":"Zhang","year":"2022","journal-title":"Biochem Cell Biol"},{"key":"R14-20260626","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/1354750X.2022.2102213","article-title":"Alloimperatorin from Ammi majus fruits mitigates piroxicam-provoked gastric ulcer and hepatorenal toxicity in rats via suppressing oxidative stress and apoptosis","volume":"27","author":"Abd-Alla","year":"2022","journal-title":"Biomarkers"},{"key":"R15-20260626","first-page":"6617312","article-title":"Studies on the mechanism of alloimperatorin on the proliferation and apoptosis of HeLa cells","author":"Bai","year":"2021","journal-title":"J Oncol 2021"},{"key":"R16-20260626","first-page":"126","article-title":"Phytochemicals and phytotherapeutic studies on different parts of aegle marmelos: A critical overview","volume":"19","author":"Yogesh","year":"2024","journal-title":"Res J Biotechnol"},{"key":"R17-20260626","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/2210299X01666230124105950","article-title":"Bioactive furanocoumarin \u201calloimperatorin\u201c: Therapeutic importance and pharmacological activities in medicine","volume":"1","author":"Patel","year":"2023","journal-title":"Curr Indian Sci"},{"key":"R18-20260626","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.fct.2018.11.014","article-title":"Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats","volume":"123","author":"Sivalingam","year":"2019","journal-title":"Food Chem Toxicol"},{"key":"R20-20260626","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/jcp.36.5.609-d","article-title":"Theory and practice of histological techniques","volume":"36","author":"Drury","year":"1983","journal-title":"J Clin Pathol"},{"key":"R21-20260626","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4149\/gpb_2023030","article-title":"Combination therapy of metformin and atorvastatin against benzopyrene-induced lung cancer via inflammatory signaling pathway","volume":"43","author":"Ning","year":"2024","journal-title":"Gen Physiol Biophys"},{"key":"R22-20260626","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s10637-008-9159-7","article-title":"Antioxidant and anticancer efficacy of hesperidin in benzo (a) pyrene induced lung carcinogenesis in mice","volume":"27","author":"Kamaraj","year":"2009","journal-title":"Invest New Drugs"},{"key":"R23-20260626","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0003-2697(78)90746-7","article-title":"A simple and sensitive method of analysis for histamine, putrescine, and polyamines without the use of an amino acid analyzer","volume":"89","author":"Endo","year":"1978","journal-title":"Anal Biochem"},{"key":"R24-20260626","doi-asserted-by":"crossref","first-page":"97","DOI":"10.37047\/jos.2022-92712","article-title":"Immunotherapy for lung cancer","volume":"9","author":"Karadurmu\u015f","year":"2023","journal-title":"J Oncol Sci"},{"key":"R25-20260626","doi-asserted-by":"crossref","first-page":"111298","DOI":"10.1016\/j.biopha.2021.111298","article-title":"Chemopreventive effects of Melastoma malabathricum L extract in mammary tumor model via inhibition of oxidative stress and inflammatory cytokines","volume":"137","author":"Kumar","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"R26-20260626","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/toxres\/tfab118","article-title":"The chemoprevention of spirulina platensis and garlic against diethylnitrosamine induced liver cancer in rats via amelioration of inflammatory cytokines expression and oxidative stress","volume":"11","author":"Abouzed","year":"2022","journal-title":"Toxicol Res (Camb)"},{"key":"R27-20260626","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3390\/biom9120871","article-title":"Lagerstroemia speciosa (L.) pers leaf extract attenuates lung tumorigenesis via alleviating oxidative stress, inflammation and apoptosis","volume":"9","author":"Mousa","year":"2019","journal-title":"Biomolecules"},{"key":"R28-20260626","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1515\/jcim-2015-0078","article-title":"Attenuation of genotoxicity, oxidative stress, apoptosis and inflammation by rutin in benzo(a)pyrene exposed lungs of mice: Plausible role of NF-\u03baB, TNF-\u03ba and Bcl-2","volume":"13","author":"Shahid","year":"2016","journal-title":"J Complement Integr Med"},{"key":"R29-20260626","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/mc.22745","article-title":"The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer","volume":"57","author":"Tao","year":"2018","journal-title":"Mol Carcinog"},{"key":"R30-20260626","doi-asserted-by":"crossref","first-page":"e2876","DOI":"10.1038\/cddis.2017.265","article-title":"Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop","volume":"8","author":"Wang","year":"2017","journal-title":"Cell Death Dis"},{"key":"R31-20260626","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1007\/s00204-013-1047-z","article-title":"Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K\/Akt and ERK and JNK signaling pathways in human lung cancer cell lines","volume":"87","author":"Hsieh","year":"2013","journal-title":"Arch Toxicol"},{"key":"R32-20260626","doi-asserted-by":"crossref","first-page":"9137","DOI":"10.1039\/D3FO02482B","article-title":"Ginsenosides: A potential natural medicine to protect the lungs from lung cancer and inflammatory lung disease","volume":"14","author":"Wang","year":"2023","journal-title":"Food Funct"},{"key":"R33-20260626","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1016\/j.fct.2012.07.037","article-title":"Antitumor and antimetastatic activities of grape skin polyphenols in a murine model of breast cancer","volume":"50","author":"Sun","year":"2012","journal-title":"Food Chem Toxicol"},{"key":"R34-20260626","doi-asserted-by":"crossref","first-page":"119638","DOI":"10.1016\/j.lfs.2021.119638","article-title":"RETRACTED: Empagliflozin and neohesperidin mitigate methotrexate hepatotoxicity via Nrf2\/PPAR\u03b3\/HO-1 signalling initiation and suppression of NF-\u03baB\/Keap1\/HSP70\/caspase-3 axis in rats","volume":"278","author":"Osman","year":"2021","journal-title":"Life Sci"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_1353_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:26:45Z","timestamp":1787747205000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_1353_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijp.ijp_1353_25","relation":{},"ISSN":["0253-7613","1998-3751"],"issn-type":[{"value":"0253-7613","type":"print"},{"value":"1998-3751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-12-24","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}