{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:23:42Z","timestamp":1787775822575,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>Hexarelin is a growth hormone secretagogue receptor type 1a agonist with a potent anti-apoptotic effect. We studied the neuroprotective effect of hexarelin on the survival of retinal ganglion cells (RGCs) in the retina following optic nerve transection (ONT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>Golden hamsters of 8\u20139 weeks old were used. For 7 days following ONT with one dose of drug, hamsters were injected with single dose of saline, 25 \u03bcg\/kg, 50 \u03bcg\/kg, and 100 \u03bcg\/kg hexarelin daily for 5 days. For 7 days after ONT with two doses of drugs, saline, 100 \u03bcg\/kg and 150 \u03bcg\/kg hexarelin were injected twice daily for 5 days. Survival of RGCs was quantified by immunostaining with Tuj1 antibody in retina whole mount.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Single daily doses of 25 \u03bcg\/kg, 50 \u03bcg\/kg, and 100 \u03bcg\/kg hexarelin dose dependently and significantly increased the survival of RGC. The survival rates of RGC in saline, 25 \u03bcg\/kg, 50 \u03bcg\/kg, and 100 \u03bcg\/kg hexarelin-treated hamsters were 51.2%, 62.4%, 68.5%, and 74.6%, respectively, in 7 days ONT. Two daily doses of saline, 100 \u03bcg\/kg and 150 \u03bcg\/kg hexarelin promoted survivals to 72.9%, 91.4%, and 109.2%, respectively, in 7 days ONT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Single daily doses of hexarelin dose dependently increased the survival of RGC. Two daily doses of hexarelin increased RGC survival further and 150 \u03bcg\/kg hexarelin twice daily is optimal for the survival of RGC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijp.ijp_176_24","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T07:00:10Z","timestamp":1772434810000},"page":"126-130","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Hexarelin promotes the survival of retinal ganglion cells after optic nerve transection"],"prefix":"10.4103","volume":"58","author":[{"given":"Kevin Bing Shui","family":"Chow","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, 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