{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:22:17Z","timestamp":1787775737188,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Neuropsychiatric disorders are widespread and serious and have a detrimental effect on the patient\u2019s physical and mental health. The aim of the present study was to find the protective effect of\n                    <jats:italic toggle=\"yes\">Rubus ellipticus<\/jats:italic>\n                    in epilepsy by maximal electroshock seizure, pentylenetetrazol, and related depressive behavior by Forced Swim Test and Tail Suspension Test. The animals were given ethanol extract of\n                    <jats:italic toggle=\"yes\">R. ellipticus<\/jats:italic>\n                    (EERE) (100, 200, or 400 mg\/kg) doses for 10 days. On every 5\n                    <jats:sup>th<\/jats:sup>\n                    day, seizure monitoring was performed (day 5 and day 10), followed by depressive behavior monitoring by evaluating immobility time. It was revealed that EERE treatment caused antidepressive-like behavior as a comorbid antiepileptogenic effect. This study will provide compelling evidence to support further clinical trials to grow this medicinal plant in the management of epileptogenic and associated debilitating behavioral comorbidities.\n                  <\/jats:p>","DOI":"10.4103\/ijp.ijp_215_23","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T21:05:23Z","timestamp":1746479123000},"page":"48-51","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Amelioration of convulsion-induced depression comorbidity by Rubus ellipticus whole plant extract in experimental models"],"prefix":"10.4103","volume":"57","author":[{"given":"Suniti","family":"Chand","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Noida Institute of Engineering and Technology (Pharmacy Institute), Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saumya","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Noida Institute of Engineering and Technology (Pharmacy Institute), Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avijit","family":"Mazumder","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Noida Institute of Engineering and Technology (Pharmacy Institute), Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swarupanjali","family":"Padhi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Noida Institute of Engineering and Technology (Pharmacy Institute), Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandana","family":"Majee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Noida Institute of Engineering and Technology (Pharmacy Institute), Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananya","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Noida Institute of Engineering and Technology (Pharmacy Institute), Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manas Kumar","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Orlean College of Pharmacy, Greater Noida, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"R1-20250506","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000503831","article-title":"The epidemiology of epilepsy","volume":"54","author":"Beghi","year":"2020","journal-title":"Neuroepidemiology"},{"key":"R2-20250506","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1080\/14737175.2016.1204233","article-title":"The comorbidity of epilepsy and depression: Diagnosis and treatment","volume":"16","author":"Tao","year":"2016","journal-title":"Expert Rev Neurother"},{"key":"R3-20250506","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1528-1167.2009.02285.x","article-title":"Recommendation for a definition of acute symptomatic seizure","volume":"51","author":"Beghi","year":"2010","journal-title":"Epilepsia"},{"key":"R4-20250506","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/j.1528-1167.2008.01945.x","article-title":"Is a first acute symptomatic seizure epilepsy? 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