{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:36:49Z","timestamp":1787841409920,"version":"build-2784847793"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:p>Acitretin is a synthetic, second-generation retinoid mainly used for the treatment of Darier\u2019s disease (DD), which impacts biological processes by binding to a nuclear receptor from the corticosteroid\/thyroid receptor superfamily, thereby altering gene expression. Our report outlines the case of a 41-year-old male patient who has received a clinical diagnosis of DD and does not exhibit any other coexisting comorbidities, who developed hypothyroidism posttreatment with acitretin, an unusual and rare side effect of the drug. His baseline routine investigations fell within normal limits before the initiation of acitretin. Acitretin-induced hypothyroidism was treated with thyroxine. Although a good therapeutic response was seen with acitretin, it could not be continued due to the development of side effects and was continued on topical therapy. This case emphasizes the likelihood of adverse effects linked to therapeutic levels of acitretin in patients without any prior history and signifies the critical importance of consistent blood monitoring throughout drug therapy.<\/jats:p>","DOI":"10.4103\/ijp.ijp_250_23","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T03:00:45Z","timestamp":1720148445000},"page":"220-223","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Acitretin induced primary hypothyroidism in Darier\u2019s disease: A rare case report"],"prefix":"10.4103","volume":"56","author":[{"given":"Betsy Susan","family":"Babu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Karnataka College of Pharmacy, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol Z.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bangalore Baptist Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balachandra","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Bangalore Baptist Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"R1-20240903","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1365-2230.1999.00416.x","article-title":"Management of Darier's disease","volume":"24","author":"Burge","year":"1999","journal-title":"Clin Exp Dermatol"},{"key":"R2-20240903","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1468-3083.2004.01096.x","article-title":"Dyskeratosis follicularis disease: Case reports and review of the literature","volume":"19","author":"Zeglaoui","year":"2005","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R3-20240903","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2165\/00128071-200304020-00003","article-title":"Darier's disease: Epidemiology, pathophysiology, and management","volume":"4","author":"Cooper","year":"2003","journal-title":"Am J Clin Dermatol"},{"key":"R5-20240903","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/ced.12078","article-title":"Treatment of Darier disease with oral alitretinoin","volume":"38","author":"Letul\u00e9","year":"2013","journal-title":"Clin Exp Dermatol"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_250_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:53:32Z","timestamp":1787838812000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_250_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":4,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijp.ijp_250_23","relation":{},"ISSN":["0253-7613","1998-3751"],"issn-type":[{"value":"0253-7613","type":"print"},{"value":"1998-3751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2023-04-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}