{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:41:39Z","timestamp":1786653699305,"version":"build-2736575974"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Hand\u2013foot skin reaction (HFSR) is a specific but uncommon cutaneous side effect mainly following chemotherapeutic drugs such as multitargeted kinase inhibitors. HFSR is reversible and non-life-threatening. HFSR, also known as palmoplantar erythrodysesthesia, presents with various degrees of erythema, edema, hyperkeratosis, blister, and sometimes with a fine white scale. Dolutegravir, a first next-generation integrase inhibitor, is used with other antiretroviral therapy (ART) to treat mainly HIV infections. HFSR is diagnosed depending on the suggestive association of drug intake and characteristic palmoplantar eruption. ART can cause several cutaneous adverse drug reactions though no case report of dolutegravir-induced HFSR has been reported till date in literature. Here, we present a case of HFSR in a seropositive male on ART.<\/jats:p>","DOI":"10.4103\/ijp.ijp_258_23","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T02:01:48Z","timestamp":1709863308000},"page":"55-57","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Dolutegravir-induced hand\u2013foot skin reaction in a seropositive male: A rare presentation"],"prefix":"10.4103","volume":"56","author":[{"given":"Tirthankar","family":"Gayen","sequence":"first","affiliation":[{"name":"Department of Dermatology, IPGME&R, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhasmita","family":"Baisya","sequence":"additional","affiliation":[{"name":"Department of Dermatology, IPGME&R, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devansi","family":"Sarawgi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, IPGME&R, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, IPGME&R, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"R1-20260504","doi-asserted-by":"crossref","first-page":"442.","DOI":"10.4081\/oncol.2020.442","article-title":"Management of cytotoxic chemotherapy-induced hand-foot syndrome","volume":"14","author":"Kwakman","year":"2020","journal-title":"Oncol Rev"},{"key":"R2-20260504","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000258880","article-title":"Hand-foot syndrome (hand-foot skin reaction, palmar-plantar erythrodysesthesia): Focus on sorafenib and sunitinib","volume":"77","author":"Lipworth","year":"2009","journal-title":"Oncology"},{"key":"R3-20260504","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1470-2045(05)70243-6","article-title":"Cutaneous side-effects of kinase inhibitors and blocking antibodies","volume":"6","author":"Robert","year":"2005","journal-title":"Lancet Oncol"},{"key":"R4-20260504","first-page":"101","article-title":"Serious hand-and-foot syndrome in black patients treated with capecitabine: Report of 3 cases and review of the literature","volume":"73","author":"Narasimhan","year":"2004","journal-title":"Cutis"},{"key":"R5-20260504","first-page":"29","article-title":"Potential benefit of dolutegravir once daily: efficacy and safety","volume":"5","author":"Fantauzzi","year":"2013","journal-title":"HIV AIDS (Auckl)"},{"key":"R6-20260504","doi-asserted-by":"crossref","first-page":"757496.","DOI":"10.1155\/2013\/757496","article-title":"Plantar erythrodysesthesia caused by antiretroviral treatment: A case report and review of the literature","volume":"2013","author":"Aigner","year":"2013","journal-title":"Case Rep Med"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_258_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:10Z","timestamp":1786650070000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_258_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijp.ijp_258_23","relation":{},"ISSN":["0253-7613","1998-3751"],"issn-type":[{"value":"0253-7613","type":"print"},{"value":"1998-3751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-05-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-29","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}