{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:58:09Z","timestamp":1791043089775,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>\n                      The objective of this study was to evaluate the efficacy and safety of topical nanoemulsion (NE)-loaded cream and gel formulations of\n                      <jats:italic toggle=\"yes\">Hippophae rhamnoides<\/jats:italic>\n                      L. (sea buckthorn [SBT]) fruit oil for wound healing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>\n                      The NE-loaded cream and gel formulations of\n                      <jats:italic toggle=\"yes\">H. rhamnoides<\/jats:italic>\n                      L. (SBT) fruit oil (IPHRFH) were prepared and evaluated for their wound-healing activity on female Sprague\u2013Dawley (SD) rats. They were further divided into groups (seven) and the wound-healing activity was determined by measuring the area of the wound on the wounding day and on the 0\n                      <jats:sup>th<\/jats:sup>\n                      , 4\n                      <jats:sup>th<\/jats:sup>\n                      , 8\n                      <jats:sup>th<\/jats:sup>\n                      , and 10\n                      <jats:sup>th<\/jats:sup>\n                      days. The acute dermal toxicity of the formulations was assessed by observing the erythema, edema, and body weight (BW) of the rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The topical NE cream and gel formulations of\n                      <jats:italic toggle=\"yes\">H. rhamnoides<\/jats:italic>\n                      L. (SBT) fruit oil showed significant wound-healing activity in female SD rats. The cream formulation of IPHRFH showed 78.96%, the gel showed 72.59% wound contraction on the 8\n                      <jats:sup>th<\/jats:sup>\n                      day, whereas the positive control soframycin (1% w\/w framycetin) had 62.29% wound contraction on the 8\n                      <jats:sup>th<\/jats:sup>\n                      day. The formulations also showed a good acute dermal toxicity profile with no changes significantly affecting BW and dermal alterations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      The results of this study indicate that topical NE-loaded cream and gel formulation of\n                      <jats:italic toggle=\"yes\">H. rhamnoides<\/jats:italic>\n                      L. (SBT) fruit oil are safe and effective for wound healing. The formulations showed no signs of acute dermal toxicity in female SD rats.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijp.ijp_370_23","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T11:50:48Z","timestamp":1714477848000},"page":"120-128","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Wound-healing effect of topical nanoemulsion-loaded cream and gel formulations of Hippophae rhamnoides L. (sea buckthorn) fruit oil and their acute dermal toxicity study on female SD rats"],"prefix":"10.4103","volume":"56","author":[{"given":"Dattatraya Dinkar","family":"Gore","sequence":"first","affiliation":[{"name":"Department of Natural Products, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashantkumar 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