{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:33:27Z","timestamp":1787841207166,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>The development and progression of chronic heart failure (CHF), hypertrophy, and remodeling strongly correlate with myocardial inflammation and oxidative stress. S-adenosylmethionine (SAMe), available as a dietary supplement, exerts anti-inflammatory and antioxidant effects. Previous reports show that by regulating angiogenesis and fibrosis, S-adenosyl-L-methionine improves ventricular remodeling. The study objectives were to investigate the cardioprotective effect of SAMe in isoproterenol (ISO)-induced CHF and explore the anti-inflammatory and antioxidant properties of SAMe in this model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODOLOGY:<\/jats:title>\n                    <jats:p>After animal ethics permission, CHF was induced using ISO of 10 mg\/kg for 14 consecutive days in 24 Wistar rats. There were four groups of six rats in each group: Sham Control, Disease Control (DC), ISO + SAMe 100 mg, and ISO + SAMe 200 mg. The variables assessed were heart to body weight ratio (HW\/BW mg\/g), bio-distribution of Flourine 18-Fluorodeoxyglucose (18F-FDG) in heart tissue, tumor necrosis factor-\u03b1 (TNF-\u03b1) and glutathione (GSH) levels in heart tissue, histopathology, and positron emission tomography imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      SAMe in ISO-induced CHF animals showed a significant decrease in the HW\/BW compared to DC group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). 18F-FDG uptake was significantly reduced by SAMe in CHF-induced rats compared to DC rats for both doses (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). SAMe showed significantly better values of both TNF-\u03b1 and GSH than the DC group in both doses (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). SAMe in both doses showed multifocal necrosis with scarring and minimal inflammatory cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>SAMe exerts a cardioprotective effect on ISO-induced CHF in rats because of its antioxidant and anti-inflammatory properties.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijp.ijp_407_24","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T05:00:30Z","timestamp":1734411630000},"page":"335-341","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Cardioprotective effect of S-adenosyl L-methionine due to antioxidant and anti-inflammatory properties on isoproterenol-induced chronic heart failure in Wistar rats"],"prefix":"10.4103","volume":"56","author":[{"given":"Sharmila Vinayak","family":"Jalgaonkar","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raakhi","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komal Gorakshanath","family":"Kurhade","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"Small Animal Imaging Facility (SAIF), ACTREC, TMC, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhabani Shankar","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Small Animal Imaging Facility (SAIF), ACTREC, TMC, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Vaideeswar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"R1-20241217","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3390\/jcm5070062","article-title":"Heart failure: Diagnosis, management and utilization","volume":"5","author":"Inamdar","year":"2016","journal-title":"J Clin Med"},{"key":"R2-20241217","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4103\/2395-5414.182988","article-title":"Heart Failure in India: The INDUS (INDia Ukieri Study) Study","volume":"2","author":"Chaturvedi","year":"2016","journal-title":"Journal of the Practice of Cardiovascular Sciences"},{"key":"R3-20241217","first-page":"691693","article-title":"Myeloperoxidase-related chlorination activity is positively associated with circulating ceruloplasmin in chronic heart failure patients: Relationship with neurohormonal, inflammatory, and nutritional parameters","author":"Cabassi","year":"2015","journal-title":"Biomed Res Int 2015"},{"issue":"Suppl 1","key":"R4-20241217","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0735-1097(20)30669-0","article-title":"Correlation of coronary inflammatory markers like high sensitive c reactive protein, tumor necrosis factor, interleukin 6 with perivascular fat attenuation index to stratify the cardiac risk associated with adverse plaque morphology","volume":"75","author":"Sen","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"R5-20241217","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ejhf.1320","article-title":"Treating oxidative stress in heart failure: Past, present and future","volume":"21","author":"van der Pol","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"R6-20241217","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.numecd.2010.08.006","article-title":"Nutritional intake and oxidative stress in chronic heart failure","volume":"22","author":"Hughes","year":"2012","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"R7-20241217","doi-asserted-by":"crossref","first-page":"e0122124","DOI":"10.1371\/journal.pone.0122124","article-title":"S-adenosyl-L-methionine for the treatment of chronic liver disease: A systematic review and meta-analysis","volume":"10","author":"Guo","year":"2015","journal-title":"PLoS One"},{"key":"R8-20241217","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1093\/ajcn\/nqab210","article-title":"Association between plasma S-adenosylmethionine and risk of mortality in patients with coronary artery disease: A cohort study","volume":"114","author":"Liu","year":"2021","journal-title":"Am J Clin Nutr"},{"key":"R9-20241217","doi-asserted-by":"crossref","first-page":"1183S","DOI":"10.1093\/ajcn\/76.5.1183S","article-title":"S-adenosyl-L-methionine: Its role in the treatment of liver disorders","volume":"76","author":"Lieber","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"R10-20241217","doi-asserted-by":"crossref","first-page":"e656","DOI":"10.4088\/JCP.16r11113","article-title":"S-adenosylmethionine (SAMe) for neuropsychiatric disorders: A clinician-oriented review of research","volume":"78","author":"Sharma","year":"2017","journal-title":"J Clin Psychiatry"},{"key":"R11-20241217","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.4314\/tjpr.v21i6.3","article-title":"S-adenosyl-L-methionine improves ventricular remodeling after myocardial infarction by regulating angiogenesis and fibrosis","volume":"21","author":"Yuanchen","year":"2022","journal-title":"Tropical Journal of Pharmaceutical Research"},{"key":"R12-20241217","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/ar.24948","article-title":"S-adenosyl methionine improves motor co-ordination with reduced oxidative stress, dopaminergic neuronal loss, and DNA methylation in the brain striatum of 6-hydroxydopamine-induced neurodegeneration in rats","volume":"306","author":"Jalgaonkar","year":"2023","journal-title":"Anat Rec (Hoboken)"},{"key":"R13-20241217","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/ar.24948","article-title":"S-adenosyl methionine improves motor coordination with reduced oxidative stress, dopaminergic neuronal loss, and DNA methylation in the brain striatum of 6-hydroxydopamine-induced neurodegeneration in rats","volume":"306","author":"Jalgaonkar","year":"2023","journal-title":"Anat Rec (Hoboken)"},{"key":"R14-20241217","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/1755-5922.12241","article-title":"Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway","volume":"35","author":"Zhou","year":"2017","journal-title":"Cardiovasc Ther"},{"key":"R15-20241217","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.nucmedbio.2017.12.006","article-title":"Imaging of isoproterenol-induced myocardial injury with (18) F labeled fluoroglucaric acid in a rat model","volume":"59","author":"Houson","year":"2018","journal-title":"Nucl Med Biol"},{"key":"R16-20241217","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/ame2.12136","article-title":"Drug-induced cardiomyopathy: Characterization of a rat model by [(18)F] FDG\/PET and [(99m) Tc] MIBI\/SPECT","volume":"3","author":"Houson","year":"2020","journal-title":"Animal Model Exp Med"},{"key":"R17-20241217","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13550-021-00799-2","article-title":"Performance of nanoScan PET\/CT and PET\/MR for quantitative imaging of (18)F and (89)Zr as compared with ex vivo biodistribution in tumor-bearing mice","volume":"11","author":"Chomet","year":"2021","journal-title":"EJNMMI Res"},{"key":"R18-20241217","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11886-018-1067-7","article-title":"Tumor necrosis factor-\u03b1 in heart failure: An updated review","volume":"20","author":"Schumacher","year":"2018","journal-title":"Curr Cardiol Rep"},{"key":"R19-20241217","first-page":"146","article-title":"Reduction in oxidative stress and modulation of heart failure subsequent to myocardial infarction in rats","volume":"10","author":"Hill","year":"2005","journal-title":"Exp Clin Cardiol"},{"key":"R20-20241217","first-page":"145","article-title":"Oxidative stress and inflammatory markers \u2013The future of heart failure diagnostics?","volume":"12","author":"Szczurek","year":"2015","journal-title":"Kardiochir Torakochirurgia Pol"},{"key":"R21-20241217","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ejhf.696","article-title":"Myocardial fibrosis: Biomedical research from bench to bedside","volume":"19","author":"Gy\u00f6ngy\u00f6si","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"R22-20241217","first-page":"2","article-title":"Isoproterenol induced heart failure in rat heart: Evaluation and cardioprotective strategy","volume":"11","author":"Bourdier","year":"2019","journal-title":"Arch Cardiovasc Dis Suppl"},{"key":"R23-20241217","doi-asserted-by":"crossref","first-page":"585163","DOI":"10.3389\/fphar.2020.585163","article-title":"Galangin attenuates isoproterenol-induced inflammation and fibrosis in the cardiac tissue of albino wistar rats","volume":"11","author":"Thangaiyan","year":"2020","journal-title":"Front Pharmacol"},{"key":"R24-20241217","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00018-013-1349-6","article-title":"The pathogenesis of cardiac fibrosis","volume":"71","author":"Kong","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"R25-20241217","doi-asserted-by":"crossref","first-page":"12591","DOI":"10.3390\/ijms222212591","article-title":"Multiparametric evaluation of post-MI small animal models using metabolic ([(18F] FDG) and perfusion-based (SYN1) heart viability tracers","volume":"22","author":"Kolanowski","year":"2021","journal-title":"Int J Mol Sci"},{"key":"R26-20241217","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s12149-007-0067-2","article-title":"Quantitative FDG-uptake by positron emission tomography in progressive hypertrophy of rat hearts in vivo","volume":"21","author":"Handa","year":"2007","journal-title":"Ann Nucl Med"},{"key":"R27-20241217","doi-asserted-by":"crossref","first-page":"e0188479","DOI":"10.1371\/journal.pone.0188479","article-title":"Evaluation of myocardial glucose metabolism in hypertrophic cardiomyopathy using 18F-fluorodeoxyglucose positron emission tomography","volume":"12","author":"Aoyama","year":"2017","journal-title":"PLoS One"},{"key":"R28-20241217","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.3390\/jcm9103267","article-title":"Complexity of TNF-\u03b1 signalling in heart disease","volume":"9","author":"Rolski","year":"2020","journal-title":"J Clin Med"},{"key":"R29-20241217","first-page":"G125","article-title":"S-adenosylmethionine deficiency and TNF-alpha in lipopolysaccharide-induced hepatic injury","volume":"275","author":"Chawla","year":"1998","journal-title":"Am J Physiol"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_407_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:45:55Z","timestamp":1787838355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijp.ijp_407_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijp.ijp_407_24","relation":{},"ISSN":["0253-7613","1998-3751"],"issn-type":[{"value":"0253-7613","type":"print"},{"value":"1998-3751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-05-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}